Simes DC, Viegas CSB, Araujo NC. Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies. 2019. |
The interplay between mineral metabolism, vascular calcification and inflammation in Chronic Kidney Disease (CKD): challenging old concepts with new facts. 2019. doi:10.18632/aging.102046 |
Viegas C, Edelweiss E, Schneider J, et al. Use of an innovative system and nanotechnology-based strategy for therapeutic applications of Gla-rich protein (GRP). Annals of Medicine. 2019;51(sup1):38 - 38. doi:10.1080/07853890.2018.1561804 |
Araújo N, Viegas C, Perrolas I, et al. Amentadione is a new modulating agent for osteoarthritis in an ex-vivo co-culture preclinical assay. Annals of Medicine. 2019;51(sup1):43 - 43. doi:10.1080/07853890.2018.1561895 |
Viegas CSB, Simes DC. A dual role for GRP in cardiovascular disease. Aging. 2019;11(5):1323 - 1324. doi:10.18632/aging.v11i510.18632/aging.101851 |
Willems BA, Furmanik M, Caron MMJ, et al. Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling. Scientific Reports. 2018;8(1). doi:10.1038/s41598-018-23353-y |
Viegas CSB, Santos L, Macedo AL, et al. Chronic Kidney Disease Circulating Calciprotein Particles and Extracellular Vesicles Promote Vascular Calcification. Arteriosclerosis, Thrombosis, and Vascular Biology. 2018;38(3):575 - 587. doi:10.1161/ATVBAHA.117.310578 |
Silva APaula, Viegas C, Simes D, et al. GLA-RICH PROTEIN AS A NOVEL MARKER FOR CALCIFICATIONS IN DIABETIC PATIENTS WITH CKD. Nephrology Dialysis Transplantation. 2018;33(suppl_1):i493 - i493. doi:10.1093/ndt/gfy104.SP430 |
Viegas CSB, Simes DC. Immunity And Inflammation In Health And Disease: Inflammation And Calcification In The Vascular Tree; Insights Into Atherosclerosis. Elsevier; 2018:189 - 201. doi:10.1016/B978-0-12-805417-8.00015-9 |
Viegas CSB, Macedo AL, Matos AA, et al. Translational Research and Innovation in Human and Health Science: Gla-rich protein, a vitamin K-dependent protein involved in inflammation and calcification-related diseases. Annals of Medicine. 2018;50(sup1):S1 - S9. doi:10.1080/07853890.2018.1427452 |
Viegas CSB, Costa RM, Santos L, et al. Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases. . de Frutos PGarcia, ed. PLOS ONE. 2017;12(5):e0177829. |
Viegas CSB, Macedo AL, Morais R, et al. Dysregulated fetuin–mineral complexes are linked to vascular calcification in chronic kidney disease: The role of Gla-rich protein. Ultrastructural Pathology. 2017;41(1):78 - 80. doi:10.1080/01913123.2016.1269490 |
Morais R, Viegas CSB, Simes DC, Matos APA, Macedo AL. Application of TEM techniques for the study of vascular calcification: Monitoring extracellular vesicles and nanogold immunodetection of fetuin-A, GRP, and CD9. Ultrastructural Pathology. 2017;41(1):130 - 132. doi:10.1080/01913123.2016.1272670 |
Viegas C, Santos L, Macedo A, et al. CIRCULATING CALCIPROTEIN PARTICLES AND EXTRACELLULAR VESICLES AS NOVEL PLAYERS IN CHRONIC KIDNEY DISEASE VASCULAR CALCIFICATION. A ROLE FOR GLA-RICH PROTEIN. Nephrology Dialysis Transplantation. 2017;32(suppl_3):iii67 - iii68. doi:10.1093/ndt/gfx123.MO055 |
Macedo AL, Viegas CSB, Matos APA, Simes DC. Extracellular Vesicles and Circulating Fetuin-Mineral Complexes in Vascular Calcification; Studies by EM Techniques. Microscopy and Microanalysis. 2016;22(S4):16 - 17. doi:10.1017/S1431927616000271 |
Viegas CSB, Simes DC. New Perspectives for the Nutritional Value of Vitamin K in Human Health. Journal of Nutritional Disorders & Therapy. 2016;6(3). doi:10.4172/2161-050910.4172/2161-0509.1000192 |
Viegas CSB, Simes DC. Gla-rich Protein (GRP): A New Player In The Burden Of Vascular Calcification. Journal of Cardiovascular Diseases & Diagnosis. 2016;4(4). doi:10.4172/2329-951710.4172/2329-9517.1000245 |
Cavaco S, Viegas CSB, Rafael MS, et al. Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis. Cell Mol Life Sci. 2016;73(5):1051-65. doi:10.1007/s00018-015-2033-9 |
Viegas CSB, Rafael MS, Enriquez JL, et al. Gla-rich protein acts as a calcification inhibitor in the human cardiovascular system. Arterioscler Thromb Vasc Biol. 2015;35(2):399-408. doi:10.1161/ATVBAHA.114.304823 |
Richard N, Engrola S, Palma PS, Simes DC, Conceição LEC. Assessment of protein digestive capacity and metabolic utilisation during ontogeny of Senegalese sole larvae: A tracer study using in vivo produced radiolabelled polypeptide fractions. Aquaculture. 2015;441:35 - 44. doi:10.1016/j.aquaculture.2015.02.003 |
Viegas CSB, Rafael MS, Enriquez JL, et al. Gla-rich protein (GRP) is a new player in mineralization-competence of extracellular vesicles involved in vascular calcification. Journal of Vascular Research. 2015;52(1):1 - 88. doi:10.1159/000433498 |
Cavaco S, Williamson MK, Rosa J, et al. Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase. Fish Physiol Biochem. 2014;40(3):731-8. doi:10.1007/s10695-013-9880-9 |
Rafael MS, Cavaco S, Viegas CSB, et al. Insights into the association of Gla-rich protein and osteoarthritis, novel splice variants and γ-carboxylation status. Mol Nutr Food Res. 2014;58(8):1636-46. doi:10.1002/mnfr.201300941 |
Viegas CSB, Herfs M, Rafael MS, et al. Gla-rich protein is a potential new vitamin K target in cancer: evidences for a direct GRP-mineral interaction. Biomed Res Int. 2014;2014:340216. doi:10.1155/2014/340216 |
Viegas CSB, Simes DC, Williamson MK, et al. Sturgeon osteocalcin shares structural features with matrix Gla protein: evolutionary relationship and functional implications. J Biol Chem. 2013;288(39):27801-11. doi:10.1074/jbc.M113.450213 |
Oliveira DV, Silva TS, Cordeiro OD, Cavaco SI, Simes DC. Identification of proteins with potential osteogenic activity present in the water-soluble matrix proteins from Crassostrea gigas nacre using a proteomic approach. ScientificWorldJournal. 2012;2012:765909. doi:10.1100/2012/765909 |
Viegas CSB, Conceição N, Fazenda C, Simes DC, M. Cancela L. Expression of Gla-rich protein (GRP) in newly developed cartilage-derived cell cultures from sturgeon ( Acipenser naccarii ). Journal of Applied Ichthyology. 2010;26(2):214 - 218. doi:10.1111/jai.2010.26.issue-210.1111/j.1439-0426.2010.01408.x |
Roberto VP, Cavaco S, Viegas CSB, et al. Matrix Gla protein in turbot (Scophthalmus maximus): Gene expression analysis and identification of sites of protein accumulation. Aquaculture. 2009;294(3-4):202 - 211. doi:10.1016/j.aquaculture.2009.06.020 |
Viegas CSB, Cavaco S, Neves PL, et al. Gla-rich protein is a novel vitamin K-dependent protein present in serum that accumulates at sites of pathological calcifications. Am J Pathol. 2009;175(6):2288-98. doi:10.2353/ajpath.2009.090474 |
Viegas CSB, Simes DC, Laizé V, Williamson MK, Price PA, M. Cancela L. Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates. J Biol Chem. 2008;283(52):36655-64. doi:10.1074/jbc.M802761200 |
Rønnestad I, Gavaia P, Viegas CSB, et al. Oligopeptide transporter PepT1 in Atlantic cod (Gadus morhua L.): cloning, tissue expression and comparative aspects. J Exp Biol. 2007;210(Pt 22):3883-96. doi:10.1242/jeb.007898 |
Ortiz-Delgado JB, Simes DC, Viegas CSB, Schaff BJ, Sarasquete C, M. Cancela L. Cloning of matrix Gla protein in a marine cartilaginous fish, Prionace glauca: preferential protein accumulation in skeletal and vascular systems. Histochem Cell Biol. 2006;126(1):89-101. doi:10.1007/s00418-005-0125-6 |
Laizé V, Viegas CSB, Price PA, M. Cancela L. Identification of an osteocalcin isoform in fish with a large acidic prodomain. Journal of Biological Chemistry. 2006;281(22):15037-15043. doi:10.1074/jbc.M600373200 |
Simões B, Conceição N, Viegas CSB, et al. Identification of a promoter element within the zebrafish colXalpha1 gene responsive to runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2alphaA2. Calcif Tissue Int. 2006;79(4):230-44. doi:10.1007/s00223-006-0111-6 |
Gavaia P, Simes DC, Ortiz-Delgado JB, et al. Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): comparative gene and protein expression during larval development through adulthood. Gene Expr Patterns. 2006;6(6):637-52. doi:10.1016/j.modgep.2005.11.010 |
Ortiz-Delgado JB, Simes DC, Gavaia P, Sarasquete C, M. Cancela L. Osteocalcin and matrix GLA protein in developing teleost teeth: identification of sites of mRNA and protein accumulation at single cell resolution. Histochem Cell Biol. 2005;124(2):123-30. doi:10.1007/s00418-005-0015-y |
Pinto JP, Conceição NM, Viegas CSB, et al. Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro. J Bone Miner Res. 2005;20(8):1440-53. doi:10.1359/JBMR.050318 |
Frazão C, Simes DC, Coelho R, et al. Structural evidence of a fourth Gla residue in fish osteocalcin: biological implications. Biochemistry. 2005;44(4):1234-42. doi:10.1021/bi048336z |
Pinto JP, Conceição NM, Viegas CSB, et al. Identification of a New pebp2αA2 Isoform From Zebrafish runx2 Capable of Inducing Osteocalcin Gene Expression In Vitro. Journal of Bone and Mineral Research. 2005;20(8):1440 - 1453. doi:10.1359/JBMR.050318 |
Laizé V, Martel P, Viegas CSB, Price PA, M. Cancela L. Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates. Journal of Biological Chemistry. 2005;280(29):26659-26668. doi:10.1074/jbc.M500257200 |
Laizé V, Martel P, Viegas CSB, Price PA, M. Cancela L. Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates. J Biol Chem. 2005;280(29):26659-68. doi:10.1074/jbc.M500257200 |
Simes DC, Williamson MK, Schaff BJ, et al. Characterization of osteocalcin (BGP) and matrix Gla protein (MGP) fish specific antibodies: validation for immunodetection studies in lower vertebrates. Calcif Tissue Int. 2004;74(2):170-80. doi:10.1007/s00223-003-0079-4 |
Simes DC, Williamson MK, Ortiz-Delgado JB, Viegas CSB, Price PA, M. Cancela L. Purification of matrix Gla protein from a marine teleost fish, Argyrosomus regius: calcified cartilage and not bone as the primary site of MGP accumulation in fish. J Bone Miner Res. 2003;18(2):244-59. doi:10.1359/jbmr.2003.18.2.244 |
Gavaia P, Ortiz JB, Simes DC, Sarasquete MC, M. Cancela L. SIMULTANEOUS DETECTION OF OSTEOCALCIN AND MATRIX GLA PROTEIN IN DEVELOPMENTAL STAGES OF ZEBRA FISH (DANIO RERIO). Calcified Tissue International. 2003;72:314 - 468. doi:10.1007/s00223-003-5002-5 |
Viegas CSB, Pinto JP, Conceição N, Simes DC, M. Cancela L. Cloning and characterization of the cDNA and gene encoding Xenopus laevis osteocalcin. Gene. 2002;289(1-2):97-107. |
Araújo NCP, Barroca PMM, Bickley JF, et al. Structural effects on sigmatropic shifts in heteroaromatic allyl ethersElectronic supplementary information (ESI) available: selected crystal data for compound 7. See http://www.rsc.org/suppdata/p1/b1/b102674g/. Journal of the Chemical Society, Perkin Transactions 1. 2002;(9):1213 - 1219. doi:10.1039/b102674g |
M. Cancela L, Ohresser MC, Reia JP, Viegas CSB, Williamson MK, Price PA. Matrix Gla protein in Xenopus laevis: molecular cloning, tissue distribution, and evolutionary considerations. J Bone Miner Res. 2001;16(9):1611-21. doi:10.1359/jbmr.2001.16.9.1611 |
Gavaia P, Viegas CSB, Pinto JP, Sarasquete MC, M. Cancela L. DETECTION AND LOCALIZATION OF OSTEOCALCIN (BGP OR BONE GLA PROTEIN) IN TELEOSTS BY IN SITU HYBRIDATION AND IMMUNOHISTOCHEMISTRY. Bone. 2001;28:S101 - S248. doi:10.1016/S8756-3282(01)00454-9 |