Evolution of matrix and bone  gamma-carboxyglutamic acid proteins in vertebrates

Vincent Laizé; Martel, Paulo; Carla SB Viegas; Price, Paul A.; M. Leonor Cancela; Bargelloni, Luca; Boudry, Pierre; Boulo, Viviane; Dias, Jorge; Huvet, Arnaud; Vincent Laizé; Lapègue, Sylvie; Leite, Ricardo; Mira, Sara; Nielsen, Einar E.; Planas, Josep V.; Roher, Nerea; Sarropoulou, Elena; Volckaert, Filip A.M.

Vincent Laizé

Posição

Senior Researcher

Grau Académico

Doutoramento

Líder do Grupo

Comparative, Adaptive and Functional Skeletal Biology

Grupo

Comparative, Adaptive and Functional Skeletal Biology

Localização

Faro, Gambelas Campus, UAlg

Gabinete

2.76

Contacto

+351 289800057

Extensão

7057

vlaize@ualg.pt

Keywords

zebrafish, extracellular matrix mineralization, bone development, marine biotechnology, osteotoxicity, gene regulation, regeneration

ORCID ID

ResearchGate

Scopus

Organiza

Informação Principal

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For more information see also the webpage of the BIOSKEL lab at http://bioskel.ccmar.ualg.pt/

Projetos

Coordenação de Projetos

	Título	Coordenador	Início	Fim	Financiamento	Orçamento	Orçamento Total
DEEPBONE	DEEPBONE - Biologia do osso de peixes de profundidade	Vincent Laizé	01/2012	06/2015	FCT - Fundação para a Ciência e Tecnologia	109k€	109k€
AQUATOX	Avaliação da toxidade óssea de poluentes aquáticos.	Vincent Laizé	07/2011	12/2014	FCT - Fundação para a Ciência e Tecnologia	113k€	113k€
SaMGP	Effect of extracellular calcium on MGP gene expression	Vincent Laizé	03/2003	03/2006		100k€	100k€

Projects Membership

	Título	Coordenador	Início	Fim	Orçamento	Orçamento Total
GERMROS	The imprinting characteristics of spermatogonia antioxidant capacity and their role in oxidative stress tolerance	Elvira Fernandez	01/2022	07/2023
ULTRAFISH	ULTRAFISH - Utilização de ultrasons na optimização da nutrição embrionária de peixes: programação nutricional do potencial de crescimento e capacidades metabólicas em juvenis.	Jorge Dias	03/2010	08/2013	190k€
SPECIAL_K	Efeitos da suplementação nutricional em vitamina K no crescimento e desenvolvimento esquelético de peixes teleósteos	Paulo Jorge Travessa Gavaia	02/2010	07/2013	195k€	195107k€

Eventos

ATT: Using Zebrafish as a model in Biomedicine and study of human diseases - 3rd Edition

21st April 2017 Organization: CCMAR Location: Universidade do Algarve - Campus de Gambelas (limited places)

Sex, 21/04/2017

Local

CCMAR - Universidade do Algarve - Campus de Gambelas (Faro)

Tipo de Evento

Seminário

Fish cell lines: Current status and future challenges

Neste seminário, o nosso investigador Vincent Laizé irá apresentar uma visão geral sobre a cultura de células de peixes.

Qua, 02/06/2021

Local

Online | Zoom platform

Tipo de Evento

Evento Científico

IAFSB 2018: 5th Conference “Interdisciplinary Approaches in Fish Skeletal Biology”

We thank all participants for joining us at IAFSB, thus making this conference possible. IAFSB conferences would also not be possible without many hours of volunteer work of the local organising...

Seg, 16/04/2018 a Qui, 19/04/2018

Local

Hotel Vila Galé Albacora, Tavira, Algarve, Portugal

Tipo de Evento

Outros Eventos

Interdisciplinary Approaches in Fish Skeletal Biology (IAFSB) 2018

The fifth conference “Interdisciplinary Approaches in Fish Skeletal Biology” takes place in Tavira, Portugal, April 16-19, 2018.

Seg, 16/04/2018 a Qui, 19/04/2018

Local

Faro

Tipo de Evento

Evento Científico

IAFSB 2009: 1st meeting "Interdisciplinary Approaches in Fish Skeletal Biology"

Seg, 27/04/2009 a Qua, 29/04/2009

Local

Tavira, Algarve, Portugal

Tipo de Evento

Evento Científico

IAFSB 2013: 3rd meeting “Interdisciplinary Approaches in Fish Skeletal Biology”

Seg, 22/04/2013 a Qua, 24/04/2013

Local

Tavira, Algarve, Portugal

Tipo de Evento

Evento Científico

IAFSB 2015: 4th Conference “Interdisciplinary Approaches in Fish Skeletal Biology”

The fourth conference “Interdisciplinary Approaches in Fish Skeletal Biology” took place in Tavira, Portugal, April 27-30, 2015.

Seg, 27/04/2015 a Qui, 30/04/2015

Local

Tavira, Algarve, Portugal

Tipo de Evento

Evento Científico

IAFSB 2011: 2nd Conference “Interdisciplinary Approaches in Fish Skeletal Biology”

O "II Interdisciplinary Approaches in Fish Skeletal Biology" Workshop pretende juntar especialistas de várias disciplinas científicas, relacionadas com a biologia do esqueleto dos peixes.

Ter, 26/04/2011 a Qui, 28/04/2011

Local

Tavira, Algarve, Portugal

Tipo de Evento

Outros Eventos

Get together CCMAR / Farewell party

Join us to a farewell party with the students from Summer School Shou (China). We're waiting for you!

Sex, 29/07/2016

Local

Building 7 - main hall

Tipo de Evento

Outros Eventos

Get together CCMAR / Welcome party

Next week, join us to welcome the students from Summer School Shou (China). We're waiting for you!

Seg, 11/07/2016

Local

Building 7 - main hall

Tipo de Evento

Outros Eventos

CCMAR recebe grupo de alunos da Universidade de Verão de Shou (China)

De 11 a 29 de Julho, 25 alunos da Universidade de Verão de Shou (China) vão ser acolhidos no Centro de Ciências do Mar (CCMAR) para acompanhar o trabalho dos nossos investigadores.

Seg, 11/07/2016

Local

Bldg. 7 - Gambelas Campus

Tipo de Evento

Seminário

GreenCoLab: Building bridges between academia and industry in algal biotechnology

No seminário desta semana vamos falar sobre o GreenCoLAB - uma organização privada sem fins lucrativos e uma plataforma colaborativa entre a investigação e a indústria.

Qua, 05/05/2021

Local

Online | Zoom platform

Tipo de Evento

Seminário

Zebrafish in vivo systems and image analysis tools to assess osteotoxicity

Marco Tarasco irá falar sobre a utilização de ferramentas de análise de imagem em sistemas de peixe zebra in vivo para avaliar o efeito tóxico de poluentes ambientais no desenvolvimento do esqueleto...

Qua, 17/03/2021

Tipo de Evento

Evento Científico

2020 CCMAR Symposium

O segundo Simpósio do CCMAR terá lugar no dia 18 de dezembro de 2020, online.

Sex, 18/12/2020

Local

online

Tipo de Evento

Seminário

Microalgae: a nutritional resource to improve zebrafish reproduction

Patrícia Diogo irá falar sobre o importante valor nutricional das microalgas que pode ser utilizado para melhorar a nutrição e o desempenho biológico do peixe-zebra (Danio rerio).

Qua, 08/07/2020

Tipo de Evento

Evento Científico

2019 CCMAR Symposium

O primeiro Simpósio do CCMAR terá lugar no dia 10 de maio de 2019, no Anfiteatro Verde da FCT, Edifício 9, Campus de Gambelas - Universidade do Algarve. As inscrições já estão abertas!

Sex, 10/05/2019

Local

Anfiteatro Verde da FCT Building 9, Gambelas Campus, University of Algarve

Notícias

News

Publicações

Year of Publication
2022	Tarasco M, Gavaia PJ, Bensimon-Brito A, et al. Effects of pristine or contaminated polyethylene microplastics on zebrafish development. Chemosphere. 2022;303:135198. doi:10.1016/j.chemosphere.2022.135198 Ler mais acerca de Effects of pristine or contaminated polyethylene microplastics on zebrafish development Google Scholar DOI
2022	Rosa JT, Tarasco M, Gavaia PJ, M. Cancela L, Laizé V. Screening of Mineralogenic and Osteogenic Compounds in Zebrafish—Tools to Improve Assay Throughput and Data Accuracy. Pharmaceuticals. 2022;15(8):983. doi:10.3390/ph15080983 Ler mais acerca de Screening of Mineralogenic and Osteogenic Compounds in Zebrafish—Tools to Improve Assay Throughput and Data Accuracy Google Scholar DOI
2022	Cardeira-da-Silva J, Bensimon-Brito A, Tarasco M, et al. Fin ray branching is defined by TRAP+ osteolytic tubules in zebrafish. Proceedings of the National Academy of Sciences. 2022;119(48). doi:10.1073/pnas.2209231119 Ler mais acerca de Fin ray branching is defined by TRAP+ osteolytic tubules in zebrafish Google Scholar DOI
2022	Laizé V, Rosa JT, Tarasco M, M. Cancela L. Status, challenges, and perspectives of fish cell culture - Focus on cell lines capable of in vitro mineralization. In: Elsevier; 2022:381 - 404. doi:10.1016/B978-0-12-822273-7.00004-5 Ler mais acerca de Status, challenges, and perspectives of fish cell culture - Focus on cell lines capable of in vitro mineralization Google Scholar DOI
2022	Pes K, Ortiz-Delgado JB, Sarasquete C, Laizé V, Fernández I. Short-term exposure to pharmaceuticals negatively impacts marine flatfish species: Histological, biochemical and molecular clues for an integrated ecosystem risk assessment. Environmental Toxicology and Pharmacology. 2022;90:103822. doi:10.1016/j.etap.2022.103822 Ler mais acerca de Short-term exposure to pharmaceuticals negatively impacts marine flatfish species: Histological, biochemical and molecular clues for an integrated ecosystem risk assessment Google Scholar DOI
2022	Moreira M, Soliño L, Marques CL, et al. Cytotoxic and hemolytic activities of extracts of the fish parasite dinoflagellate Amyloodinium ocellatum. Toxins. 2022;14(7):467. doi:10.3390/toxins14070467 Ler mais acerca de Cytotoxic and hemolytic activities of extracts of the fish parasite dinoflagellate Amyloodinium ocellatum Google Scholar DOI
2021	Rosa JT, Laizé V, Gavaia PJ, Cancela ML. Fish models of induced osteoporosis. Frontiers in Cell and Developmental Biology. 2021;9:672424. doi:10.3389/fcell.2021.672424 Ler mais acerca de Fish models of induced osteoporosis Google Scholar DOI
2021	Varela T, Conceição N, Laizé V, Cancela ML. Transcriptional regulation of human DUSP4 gene by cancer‐related transcription factors. Journal of Cellular Biochemistry. 2021;122(10):1556 - 1566. doi:10.1002/jcb.v122.1010.1002/jcb.30078 Ler mais acerca de Transcriptional regulation of human DUSP4 gene by cancer‐related transcription factors Google Scholar DOI
2021	Roberto VP, Surget G, Le Lann K, et al. Antioxidant, mineralogenic and osteogenic activities of Spartina alterniflora and Salicornia fragilis extracts rich in polyphenols. Frontiers in Nutrition. 2021;8:719438. doi:10.3389/fnut.2021.71943810.3389/fnut.2021.719438.s001 Ler mais acerca de Antioxidant, mineralogenic and osteogenic activities of Spartina alterniflora and Salicornia fragilis extracts rich in polyphenols Google Scholar DOI
2021	Tarasco M, Gavaia PJ, Bensimon-Brito A, et al. New insights into benzo[⍺]pyrene osteotoxicity in zebrafish. Ecotoxicology and Environmental Safety. 2021;226:112838. doi:10.1016/j.ecoenv.2021.112838 Ler mais acerca de New insights into benzo[⍺]pyrene osteotoxicity in zebrafish Google Scholar DOI
2021	Cancela ML, Laizé V, Conceição N, Kempf H, Murshed M. Keutel syndrome, a review of 50 years of literature. Frontiers in Cell and Developmental Biology. 2021;9:642136. doi:10.3389/fcell.2021.642136 Ler mais acerca de Keutel syndrome, a review of 50 years of literature Google Scholar DOI
2021	Pes K, Friese A, Cox CJ, Laizé V, Fernández I. Biochemical and molecular responses of the Mediterranean mussel (Mytilus galloprovincialis) to short-term exposure to three commonly prescribed drugs. Marine Environmental Research. 2021;168:105309. doi:10.1016/j.marenvres.2021.105309 Ler mais acerca de Biochemical and molecular responses of the Mediterranean mussel (Mytilus galloprovincialis) to short-term exposure to three commonly prescribed drugs Google Scholar DOI
2020	Tarasco M, Martins G, Gavaia PJ, Bebianno MJ, M. Cancela L, Laizé V. ZEB316: A Small Stand-Alone Housing System to Study Microplastics in Small Teleosts. Zebrafish. 2020;17(1):18-26. doi:10.1089/zeb.2019.1801 Ler mais acerca de ZEB316: A Small Stand-Alone Housing System to Study Microplastics in Small Teleosts Google Scholar DOI
2020	Tarasco M, Cordelières FP, M. Cancela L, Laizé V. ZFBONE: An ImageJ toolset for semi-automatic analysis of zebrafish bone structures. Bone. 2020;138:115480. doi:10.1016/j.bone.2020.115480 Ler mais acerca de ZFBONE: An ImageJ toolset for semi-automatic analysis of zebrafish bone structures Google Scholar EN DOI
2020	Beato S, Marques C, Laizé V, Gavaia PJ, Fernández I. New Insights on Vitamin K Metabolism in Senegalese sole (Solea senegalensis) Based on Ontogenetic and Tissue-Specific Vitamin K Epoxide Reductase Molecular Data. International Journal of Molecular Sciences. 2020;21(10):3489. doi:10.3390/ijms21103489 Ler mais acerca de New Insights on Vitamin K Metabolism in Senegalese sole (Solea senegalensis) Based on Ontogenetic and Tissue-Specific Vitamin K Epoxide Reductase Molecular Data Google Scholar DOI
2020	Vijayakumar P, Cardeira J, Laizé V, Gavaia PJ, M. Cancela L. Cells Isolated from Regenerating Caudal Fin of Sparus aurata Can Differentiate into Distinct Bone Cell Lineages. Marine Biotechnology. 2020;22(3):333 - 347. doi:10.1007/s10126-019-09937-3 Ler mais acerca de Cells Isolated from Regenerating Caudal Fin of Sparus aurata Can Differentiate into Distinct Bone Cell Lineages Google Scholar DOI
2020	Viegas MN, Laizé V, Salgado MA, Aguiar C, Dias J. Effect of Trace Minerals and B Vitamins on the Proliferation/Cytotoxicity and Mineralization of a Gilthead Seabream Bone–Derived Cell Line. Biological Trace Element Research. 2020;196(2):629 - 638. doi:10.1007/s12011-019-01939-5 Ler mais acerca de Effect of Trace Minerals and B Vitamins on the Proliferation/Cytotoxicity and Mineralization of a Gilthead Seabream Bone–Derived Cell Line Google Scholar DOI
2020	Varela T, Laizé V, Conceição N, et al. Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer. Biomarkers in Medicine. 2020;14(8):639 - 650. doi:10.2217/bmm-2019-0369 Ler mais acerca de Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer Google Scholar DOI
2020	Vijayakumar P, M. Cancela L, Laizé V. Isolation, Culture, and Differentiation of Blastema Cells from the Regenerating Caudal Fin of Zebrafish. Fishes. 2020;5(1):6. doi:10.3390/fishes5010006 Ler mais acerca de Isolation, Culture, and Differentiation of Blastema Cells from the Regenerating Caudal Fin of Zebrafish Google Scholar DOI
2019	Navarro-Guillén C, Dias J, Rocha F, et al. Does a ghrelin stimulus during zebrafish embryonic stage modulate its performance on the long-term?. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 2019;228:1 - 8. doi:10.1016/j.cbpa.2018.10.019 Ler mais acerca de Does a ghrelin stimulus during zebrafish embryonic stage modulate its performance on the long-term? Google Scholar DOI
2019	Tarasco M, Cardeira J, Viegas M, et al. Anti-osteogenic activity of cadmium in zebrafish. Fishes. 2019;4(1):11. doi:10.3390/fishes4010011 Ler mais acerca de Anti-osteogenic activity of cadmium in zebrafish Google Scholar DOI
2019	Granadeiro L, Dirks RP, Ortiz-Delgado JB, et al. Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner – From molecular mechanisms to environmental concerns. Ecotoxicology and Environmental Safety. 2019;181:559 - 571. doi:10.1016/j.ecoenv.2019.06.042 Ler mais acerca de Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner – From molecular mechanisms to environmental concerns Google Scholar DOI
2018	Cardeira J, Laizé V, Martins G, M. Cancela L, Gavaia P. An overview on the teleost bone mechanophysiology. Journal of Applied Ichthyology. 2018. doi:10.1111/jai.13661 Ler mais acerca de An overview on the teleost bone mechanophysiology Google Scholar DOI
2018	Carson MA, Nelson J, M. Cancela L, et al. Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae. Scientific Reports. 2018;8(1). doi:10.1038/s41598-018-26024-0 Ler mais acerca de Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae Google Scholar DOI
2018	Laizé V, Gavaia P, Tarasco M, et al. Osteotoxicity of 3-methylcholanthrene in fish. Ecotoxicology and Environmental Safety. 2018;161:721 - 728. doi:10.1016/j.ecoenv.2018.06.035 Ler mais acerca de Osteotoxicity of 3-methylcholanthrene in fish Google Scholar DOI
2018	Carson MA, Nelson J, M. Cancela L, et al. Screening for osteogenic activity in extracts from Irish marine organisms: The potential of Ceramium pallidum. Cray JJ, ed. PLOS ONE. 2018;13(11):e0207303. doi:10.1371/journal.pone.0207303.s008 Ler mais acerca de Screening for osteogenic activity in extracts from Irish marine organisms: The potential of Ceramium pallidum Google Scholar DOI
2018	Fernández I, Gavaia P, Laizé V, M. Cancela L. Fish as a model to assess chemical toxicity in bone. Aquatic Toxicology. 2018;194:208 - 226. doi:10.1016/j.aquatox.2017.11.015 Ler mais acerca de Fish as a model to assess chemical toxicity in bone Google Scholar DOI
2018	Rosa J, Cox CJ, M. Cancela L, Laizé V. Identification of a fish short-chain dehydrogenase/reductase associated with bone metabolism. Gene. 2018;645:137 - 145. doi:10.1016/j.gene.2017.12.021 Ler mais acerca de Identification of a fish short-chain dehydrogenase/reductase associated with bone metabolism Google Scholar DOI
2017	Tarasco M, Laizé V, Cardeira J, M. Cancela L, Gavaia P. The zebrafish operculum: A powerful system to assess osteogenic bioactivities of molecules with pharmacological and toxicological relevance. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2017;197:45 - 52. doi:10.1016/j.cbpc.2017.04.006 Ler mais acerca de The zebrafish operculum: A powerful system to assess osteogenic bioactivities of molecules with pharmacological and toxicological relevance Google Scholar DOI
2017	Marques C, Roberto VP, Granadeiro L, et al. The xenobiotic sensor PXR in a marine flatfish species ( Solea senegalensis ): Gene expression patterns and its regulation under different physiological conditions. Marine Environmental Research. 2017;130:187-199. doi:10.1016/j.marenvres.2017.07.021 Ler mais acerca de The xenobiotic sensor PXR in a marine flatfish species ( Solea senegalensis ): Gene expression patterns and its regulation under different physiological conditions Google Scholar DOI
2016	Cardeira J, Gavaia P, Fernández I, et al. Quantitative assessment of the regenerative and mineralogenic performances of the zebrafish caudal fin. Scientific Reports. 2016;6:39191. doi:10.1038/srep39191 Ler mais acerca de Quantitative assessment of the regenerative and mineralogenic performances of the zebrafish caudal fin Google Scholar DOI
2014	Laizé V, Gavaia P, M. Cancela L. Fish: a suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities. Drug Discovery Today: Disease Models. 2014;13:29-37. doi:10.1016/j.ddmod.2014.08.001 Ler mais acerca de Fish: a suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities Google Scholar DOI
2012	Viegas MN, Dias J, M. Cancela L, Laizé V. Polyunsaturated fatty acids regulate cell proliferation, extracellular matrix mineralization and gene expression in a gilthead seabream skeletal cell line. Journal of Applied Ichthyology. 2012;28(3):427-432. doi:10.1111/j.1439-0426.2012.01994.x Ler mais acerca de Polyunsaturated fatty acids regulate cell proliferation, extracellular matrix mineralization and gene expression in a gilthead seabream skeletal cell line Google Scholar DOI
2010	Rosa J, Tiago DM, Dias J, M. Cancela L, Laizé V. Serum-specific stimulation of proliferation and mineralization of fish bone-derived cells. Journal of Applied Ichthyology. 2010;26(2):251 - 256. doi:10.1111/jai.2010.26.issue-210.1111/j.1439-0426.2010.01414.x Ler mais acerca de Serum-specific stimulation of proliferation and mineralization of fish bone-derived cells Google Scholar DOI
2010	Rafael MS, Marques CL, Parameswaran V, M. Cancela L, Laizé V. Fish bone-derived cell lines: an alternative in vitro cell system to study bone biology. Journal of Applied Ichthyology. 2010;26(2):230-234. doi:10.1111/jai.2010.26.issue-210.1111/j.1439-0426.2010.01411.x Ler mais acerca de Fish bone-derived cell lines: an alternative in vitro cell system to study bone biology Google Scholar DOI
2010	M. Cancela L, Bargelloni L, Boudry P, et al. Genomic approaches in aquaculture and fisheries. In: J. Cock M, Tessmar-Raible K, Boyen C, Viard F, eds. Introduction To Marine Genomics. Introduction to marine genomics. Dordrecht: Springer Netherlands; 2010:213-286. doi:10.1007/978-90-481-8639-610.1007/978-90-481-8639-6_7 Ler mais acerca de Genomic approaches in aquaculture and fisheries Google Scholar DOI
2006	Laizé V, Viegas CSB, Price PA, M. Cancela L. Identification of an osteocalcin isoform in fish with a large acidic prodomain. Journal of Biological Chemistry. 2006;281(22):15037-15043. doi:10.1074/jbc.M600373200 Ler mais acerca de Identification of an osteocalcin isoform in fish with a large acidic prodomain Google Scholar DOI
2006	Braga D, Laizé V, Tiago DM, M. Cancela L. Enhanced DNA transfer into fish bone cells using polyethylenimine. Molecular Biotechnology. 2006;34(1):51-54. doi:10.1385/MB:34:110.1385/MB:34:1:51 Ler mais acerca de Enhanced DNA transfer into fish bone cells using polyethylenimine Google Scholar DOI
2005	Fonseca VG, Lago-Lestón A, Laizé V, M. Cancela L. Rapid identification of differentially expressed genes by in situ screening of bacteria. Molecular Biotechnology. 2005;30(2):163-166. doi:10.1385/MB:30:210.1385/MB:30:2:163 Ler mais acerca de Rapid identification of differentially expressed genes by in situ screening of bacteria Google Scholar DOI
2005	Laizé V, Martel P, Viegas CSB, Price PA, M. Cancela L. Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates. Journal of Biological Chemistry. 2005;280(29):26659-26668. doi:10.1074/jbc.M500257200 Ler mais acerca de Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates Google Scholar DOI