Reappraisal of four different approaches for finding the mean reaction time in the multi-trap variant of the Adam–Delbrück problem

Martins, Jorge; Melo, Eurico; Naqvi, K. Razi; Duarte, Rui; Martins, Jorge; Gutiérrez-Merino, Carlos; Moura, José J.G.; Aureliano, Manuel; Simão, Teresa; Alrokayan, Salman; Sauer, Sascha; Dahlman-Wright, Karin; Zierath, Juleen R.; Groen, Albert K.; Ruas, Jorge L.

Marine Molecular Bioengineering

Short Title

MMB

Descrição

The Marine Molecular Bioengineering (MBB) research group integrates a range of cross-disciplinary expertise that focuses on the integration of biology with biophysics and bioengineering.

The current main objective of the MMB group is the development and application of nano- and bio-technological tools and materials, including their toxicological assessment, to marine sciences.

Coordenador

Rui Borges

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The MMB group contributes with bioengineering and fundamental research methodologies and tools to the general CCMAR research in marine biology, currently with the main focus on nanotechnological methodologies and applications to environment and human health issues.

The current activities of the MMB group include the development of polymeric-based nano and microcarriers for drug delivery, the development of biosensor and calorimetric techniques for both basic and applied research, the characterisation of model membranes for various applications, and the toxicological assessment of new drugs and materials.

MMB is comprised of five researchers with different backgrounds but complementary expertises shared through four labs: Bioengineering and Molecular Energetics, Drug Delivery, Biomembranes, and Pharmacogenomics and Molecular Toxicology. MMB also runs the new CCMAR Biological Spectroscopy Lab, dedicated to fundamental and applied research on biophysical-chemistry, namely on photosynthesis of marine organisms.

Within these labs, the group has the combined expertises and experimental facilities to address both the fundamental and technological aspects of the sustainable exploration of marine materials, aiming at unlocking their potential to the objectives above.

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Coordenador	Posição
Rui Borges	Senior Researcher

Nome	Posição
Ana Grenha	Senior Researcher
Filipa Raquel Horta Guerreiro	PhD Student
Flávia Garcez Musacchio
Jorge Filipe Rodrigues Pontes	PhD Student
Jorge Martins	Senior Researcher
Luis Braz	Investigador
Noelia Flórez Fernández	Postdoc
Vera Ribeiro	Senior Researcher

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Ana Grenha

Posição:

Senior Researcher

Filipa Raquel Horta Guerreiro

Posição:

PhD Student

Flávia Garcez Musacchio

Posição:

Jorge Filipe Rodrigues Pontes

Posição:

PhD Student

Jorge Martins

Posição:

Senior Researcher

Luis Braz

Posição:

Investigador

Noelia Flórez Fernández

Posição:

Postdoc

Vera Ribeiro

Posição:

Senior Researcher

Galeria

Publicações

Todas publicações


Bebianno MJ, Rocha TL, Pontes JF, Amaral AC, Grenha A. Potential Ecotoxicological Risk of Nanopharmaceuticals in the Aquatic Environment. In: Nanopharmaceuticals: Principles And Applications Vol. 2. Nanopharmaceuticals: Principles and Applications Vol. 2. Springer International Publishing; 2020:289 - 317. doi:10.1007/978-3-030-44921-610.1007/978-3-030-44921-6_8 Ler mais acerca de Potential Ecotoxicological Risk of Nanopharmaceuticals in the Aquatic Environment Google Scholar EN DOI
Pontes JF, Braz L, Guerreiro F, et al. Sulphated locust bean gum-coated lipid nanocapsules as potential lung delivery carriers. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2020;33(2). doi:https://doi.org/10.1089/jamp.2020.ab01.abstracts Ler mais acerca de Sulphated locust bean gum-coated lipid nanocapsules as potential lung delivery carriers Google Scholar DOI
Pontes JF, Grenha A. Multifunctional Nanocarriers for Lung Drug Delivery. Nanomaterials. 2020;10(2):183. doi:10.3390/nano10020183 Ler mais acerca de Multifunctional Nanocarriers for Lung Drug Delivery Google Scholar DOI
Guerreiro F, Pontes JF, da Costa AMRosa, Grenha A. Spray-drying of konjac glucomannan to produce microparticles for an application as antitubercular drug carriers. Powder Technology. 2019;342:246-252. doi:10.1016/j.powtec.2018.09.068 Ler mais acerca de Spray-drying of konjac glucomannan to produce microparticles for an application as antitubercular drug carriers Google Scholar DOI
Rodrigues S, Alves AD, Cavaco JS, et al. Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles. International Journal of Pharmaceutics. 2017;529(1-2):433-441. doi:10.1016/j.ijpharm.2017.06.088 Ler mais acerca de Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles Google Scholar DOI
Braz L, Grenha A, Ferreira D, da Costa AMRosa, Gamazo C, Sarmento B. Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization. International Journal of Biological Macromolecules. 2017;96:786 - 797. doi:10.1016/j.ijbiomac.2016.12.076 Ler mais acerca de Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization Google Scholar DOI
Alves AD, Cavaco JS, Guerreiro F, Lourenço JP, da Costa AMRosa, Grenha A. Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles. Molecules. 2016;21(6). doi:10.3390/molecules21060702 Ler mais acerca de Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles. Google Scholar PubMed DOI
Cunha L, Grenha A. Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications. Marine Drugs. 2016;14(3):42. doi:10.3390/md14030042 Ler mais acerca de Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications Google Scholar DOI
Dionísio M, Braz L, Corvo M, Lourenço JP, Grenha A, da Costa AMRosa. Charged pullulan derivatives for the development of nanocarriers by polyelectrolyte complexation. International Journal of Biological Macromolecules. 2016;86:129 - 138. doi:10.1016/j.ijbiomac.2016.01.054 Ler mais acerca de Charged pullulan derivatives for the development of nanocarriers by polyelectrolyte complexation Google Scholar DOI
Canto AMTM do, Santos PD, Martins J, Loura LMS. Behavior of pyrene as a polarity probe in palmitoylsphingomyelin and palmitoylsphingomyelin/cholesterol bilayers: A molecular dynamics simulation study. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2015;480:296 - 306. doi:10.1016/j.colsurfa.2014.12.012 Ler mais acerca de Behavior of pyrene as a polarity probe in palmitoylsphingomyelin and palmitoylsphingomyelin/cholesterol bilayers: A molecular dynamics simulation study Google Scholar DOI
Santos MA dos, Grenha A. Advances In Protein Chemistry And Structural Biologyprotein And Peptide Nanoparticles For Drug Deliverypolysaccharide Nanoparticles For Protein And Peptide Delivery. Vol. 98. Elsevier; 2015:223 - 261. doi:10.1016/bs.apcsb.2014.11.003 Ler mais acerca de Advances in Protein Chemistry and Structural BiologyProtein and Peptide Nanoparticles for Drug DeliveryPolysaccharide Nanoparticles for Protein and Peptide Delivery Google Scholar DOI
Ebadzad G, Medeira C, Maia I, Martins J, Cravador A. Induction of defence responses by cinnamomins against Phytophthora cinnamomi in Quercus suber and Quercus ilex subs. rotundifolia. European Journal of Plant Pathology. 2015;143(4):705 - 723. doi:10.1007/s10658-015-0721-9 Ler mais acerca de Induction of defence responses by cinnamomins against Phytophthora cinnamomi in Quercus suber and Quercus ilex subs. rotundifolia Google Scholar DOI
Rodrigues S, Grenha A. Activation of Macrophages: Establishing a Role for Polysaccharides in Drug Delivery Strategies Envisaging Antibacterial Therapy. Current Pharmaceutical Design. 2015;21(33):4869 - 4887. doi:10.2174/1381612821666150820103910 Ler mais acerca de Activation of Macrophages: Establishing a Role for Polysaccharides in Drug Delivery Strategies Envisaging Antibacterial Therapy Google Scholar DOI
Rodrigues S, Cardoso L, da Costa A, Grenha A. Biocompatibility and Stability of Polysaccharide Polyelectrolyte Complexes Aimed at Respiratory Delivery. Materials. 2015;8(9):5647 - 5670. doi:10.3390/ma8095268 Ler mais acerca de Biocompatibility and Stability of Polysaccharide Polyelectrolyte Complexes Aimed at Respiratory Delivery Google Scholar DOI
Rodrigues S, Cordeiro C, Seijo B, Remuñán-López C, Grenha A. Hybrid nanosystems based on natural polymers as protein carriers for respiratory delivery: Stability and toxicological evaluation. Carbohydrate Polymers. 2015;123:369 - 380. doi:10.1016/j.carbpol.2015.01.048 Ler mais acerca de Hybrid nanosystems based on natural polymers as protein carriers for respiratory delivery: Stability and toxicological evaluation Google Scholar DOI
Correia JC, Massart J, de Boer JFreark, et al. Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism. Molecular Metabolism. 2015;4(12):891 - 902. doi:10.1016/j.molmet.2015.09.005 Ler mais acerca de Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism Google Scholar DOI
Grenha A. Editorial (Thematic Issue: Exploring the Role of Polysaccharides in Drug Delivery). Current Pharmaceutical Design. 2015;21(33):4773 - 4774. doi:10.2174/1381612821999150903143853 Ler mais acerca de Editorial (Thematic Issue: Exploring the Role of Polysaccharides in Drug Delivery) Google Scholar DOI
Mouffouk F, Dornelle D, Lopes A, et al. Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging. International Journal of Nanomedicine. 2014:63. doi:10.2147/IJN.S71190 Ler mais acerca de Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging Google Scholar DOI
Perestrelo ARubina, Grenha A, da Costa AMRosa, Belo JAntónio. Locust bean gum as an alternative polymeric coating for embryonic stem cell culture. Materials Science and Engineering: C. 2014;40:336 - 344. doi:10.1016/j.msec.2014.04.022 Ler mais acerca de Locust bean gum as an alternative polymeric coating for embryonic stem cell culture Google Scholar DOI
Nunes R, Rodrigues S, Pasko P, Tyszka-Czochara M, Grenha A, de Carvalho ISaraiva. Effect of Erica australis extract on Caco-2 cells, fibroblasts and selected pathogenic bacteria responsible for wound infection. Industrial Crops and Products. 2014;52:99 - 104. doi:10.1016/j.indcrop.2013.10.015 Ler mais acerca de Effect of Erica australis extract on Caco-2 cells, fibroblasts and selected pathogenic bacteria responsible for wound infection Google Scholar DOI
Dionísio M, Cordeiro C, Remuñán-López C, Seijo B, da Costa AMRosa, Grenha A. Pullulan-based nanoparticles as carriers for transmucosal protein delivery. European Journal of Pharmaceutical Sciences. 2013;50(1):102 - 113. doi:10.1016/j.ejps.2013.04.018 Ler mais acerca de Pullulan-based nanoparticles as carriers for transmucosal protein delivery Google Scholar DOI
Loura LMS, Canto AMTMarti, Martins J. Sensing hydration and behavior of pyrene in POPC and POPC/cholesterol bilayers: A molecular dynamics study. Biochimica et Biophysica Acta (BBA) - Biomembranes. 2013;1828(3):1094 - 1101. doi:10.1016/j.bbamem.2012.12.014 Ler mais acerca de Sensing hydration and behavior of pyrene in POPC and POPC/cholesterol bilayers: A molecular dynamics study Google Scholar DOI
Costa H, Grenha A. Natural carriers for application in tuberculosis treatment. Journal of Microencapsulation. 2013;30(3):295 - 306. doi:10.3109/02652048.2012.726283 Ler mais acerca de Natural carriers for application in tuberculosis treatment Google Scholar DOI
Ribeiro AL, Ribeiro V. Drug Metabolism and Transport Under Hypoxia. Current Drug Metabolism. 2013;14(9):969 - 975. doi:10.2174/1389200211314090003 Ler mais acerca de Drug Metabolism and Transport Under Hypoxia Google Scholar DOI
Grenha A, Rodrigues S. Pullulan-based nanoparticles: future therapeutic applications in transmucosal protein delivery. Therapeutic Delivery. 2013;4(11):1339 - 1341. doi:10.4155/tde.13.99 Ler mais acerca de Pullulan-based nanoparticles: future therapeutic applications in transmucosal protein delivery Google Scholar DOI
Rodrigues S, Dionísio M, López CRemuñán, Grenha A. Biocompatibility of Chitosan Carriers with Application in Drug Delivery. Journal of Functional Biomaterials. 2012;3(4):615 - 641. doi:10.3390/jfb3030615 Ler mais acerca de Biocompatibility of Chitosan Carriers with Application in Drug Delivery Google Scholar DOI
Grenha A, Dionísio M. Locust bean gum: Exploring its potential for biopharmaceutical applications. Journal of Pharmacy and Bioallied Sciences. 2012;4(3):175. doi:10.4103/0975-7406.99013 Ler mais acerca de Locust bean gum: Exploring its potential for biopharmaceutical applications Google Scholar DOI
Rodrigues S, da Costa AMRosa, Grenha A. Chitosan/carrageenan nanoparticles: Effect of cross-linking with tripolyphosphate and charge ratios. Carbohydrate Polymers. 2012;89(1):282 - 289. doi:10.1016/j.carbpol.2012.03.010 Ler mais acerca de Chitosan/carrageenan nanoparticles: Effect of cross-linking with tripolyphosphate and charge ratios Google Scholar DOI
Grenha A. Chitosan nanoparticles: a survey of preparation methods. Journal of Drug Targeting. 2012;20(4):291 - 300. doi:10.3109/1061186X.2011.654121 Ler mais acerca de Chitosan nanoparticles: a survey of preparation methods Google Scholar DOI
Al-Qadi S, Grenha A, Carrión-Recio D, Seijo B, Remuñán-López C. Microencapsulated chitosan nanoparticles for pulmonary protein delivery: In vivo evaluation of insulin-loaded formulations. Journal of Controlled Release. 2012;157(3):383 - 390. doi:10.1016/j.jconrel.2011.08.008 Ler mais acerca de Microencapsulated chitosan nanoparticles for pulmonary protein delivery: In vivo evaluation of insulin-loaded formulations Google Scholar DOI
Martins J, Arrais D, Manuel M. Can pyrene be localized inside lipid bilayers by simultaneously measuring Py values, and fulfilling the excimer formation conditions?. Chemistry and Physics of Lipids. 2012;165(8):866 - 869. doi:10.1016/j.chemphyslip.2012.03.005 Ler mais acerca de Can pyrene be localized inside lipid bilayers by simultaneously measuring Py values, and fulfilling the excimer formation conditions? Google Scholar DOI
Mouffouk F, da Costa AMRosa, Martins J, Zourob M, Abu-Salah KMustafa, Alrokayan SA. Development of a highly sensitive bacteria detection assay using fluorescent pH-responsive polymeric micelles. Biosensors and Bioelectronics. 2011;26(8):3517 - 3523. doi:10.1016/j.bios.2011.01.037 Ler mais acerca de Development of a highly sensitive bacteria detection assay using fluorescent pH-responsive polymeric micelles Google Scholar DOI
Félix RC, Müller P, Ribeiro V, Ranson H, Silveira H. Plasmodium infection alters Anopheles gambiae detoxification gene expression. BMC Genomics. 2010;11(1):312. doi:10.1186/1471-2164-11-312 Ler mais acerca de Plasmodium infection alters Anopheles gambiae detoxification gene expression Google Scholar DOI
Manuel M, Martins J. Partitioning of 1-pyrenesulfonate into zwitterionic and mixed zwitterionic/anionic fluid phospholipid bilayers. Chemistry and Physics of Lipids. 2008;154(2):79 - 86. doi:10.1016/j.chemphyslip.2008.04.007 Ler mais acerca de Partitioning of 1-pyrenesulfonate into zwitterionic and mixed zwitterionic/anionic fluid phospholipid bilayers Google Scholar DOI
Arrais D, Martins J. Bilayer polarity and its thermal dependency in the ℓo and ℓd phases of binary phosphatidylcholine/cholesterol mixtures. Biochimica et Biophysica Acta (BBA) - Biomembranes. 2007;1768(11):2914 - 2922. doi:10.1016/j.bbamem.2007.08.012 Ler mais acerca de Bilayer polarity and its thermal dependency in the ℓo and ℓd phases of binary phosphatidylcholine/cholesterol mixtures Google Scholar DOI
Melo E, Martins J. Kinetics of bimolecular reactions in model bilayers and biological membranes. A critical review. Biophysical Chemistry. 2006;123(2-3):77 - 94. doi:10.1016/j.bpc.2006.05.003 Ler mais acerca de Kinetics of bimolecular reactions in model bilayers and biological membranes. A critical review Google Scholar DOI
Ramos S, Manuel M, Tiago T, et al. Decavanadate interactions with actin: Inhibition of G-actin polymerization and stabilization of decameric vanadate. Journal of Inorganic Biochemistry. 2006;100(11):1734 - 1743. doi:10.1016/j.jinorgbio.2006.06.007 Ler mais acerca de Decavanadate interactions with actin: Inhibition of G-actin polymerization and stabilization of decameric vanadate Google Scholar DOI
Martins J, Melo E, K. Naqvi R. Reappraisal of four different approaches for finding the mean reaction time in the multi-trap variant of the Adam–Delbrück problem. The Journal of Chemical Physics. 2004;120(19):9390 - 9393. doi:10.1063/1.1711592 Ler mais acerca de Reappraisal of four different approaches for finding the mean reaction time in the multi-trap variant of the Adam–Delbrück problem Google Scholar DOI

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