XtremeBio | - CCMAR -


Short Title 

We are engaged in the smart and sustainable exploitation of marine resources, including micro- and macroalgae, seagrasses, marine invertebrates and also coastal plants (halophytes).




Our research is divided in 5 sub areas: XtremeFoods (for human nutrition); XtremePharma (for pharmaceutical uses), XtremeVet (for veterinary aplications); XtremeBeauty (for cosmetics) and XtremeCrops (Production of selected species).

Most relevant expected contributions of this research team includes the development and optimization of innovative commercial products incorporating active extracts from selected marine species, to be used in different commercial areas, and of sustainable cultivation technologies, such as in vitro techniques, greenhouse cultivation and IMTA systems, aiming the production of biomass and ingredients for commercial purposes.



Membros atuais (ver em tabela)
Coordinator Posição
Luísa Custódio Senior Researcher
Membros atuais (ver em grelha)
Retrato de Catarina Guerreiro Pereira
PhD Student
Retrato de Cristiana do Couto Pereira Maia
PhD Student
Retrato de Luísa Custódio
Senior Researcher
Retrato de Maria João da Silva Rodrigues
PhD Student
Retrato de Marta Oliveira
All Publications 
Rodrigues MJoão, Slusarczyk S, Pecio Ł, et al. In vitro and in silico approaches to appraise Polygonum maritimum L. as a source of innovative products with anti-ageing potential. Industrial Crops and Products. 2018;111:391 - 399. doi:10.1016/j.indcrop.2017.10.046
Rocha MI, Rodrigues MJ, Pereira C, et al. Biochemical profile and in vitro neuroprotective properties of Carpobrotus edulis L., a medicinal and edible halophyte native to the coast of South Africa. South African Journal of Botany. 2017;111:222 - 231. doi:10.1016/j.sajb.2017.03.036
Pereira CGuerreiro, Barreira L, Bijttebier S, et al. Chemical profiling of infusions and decoctions of Helichrysum italicum subsp. picardii by UHPLC-PDA-MS and in vitro biological activities comparatively with green tea ( Camellia sinensis ) and rooibos tisane ( Aspalathus linearis ). Journal of Pharmaceutical and Biomedical Analysis. 2017;145:593 - 603. doi:10.1016/j.jpba.2017.07.007
Oliveira M, Rodrigues MJoão, Pereira C, et al. First report of the in vitro antileishmanial properties of extremophile plants from the Algarve Coast. Natural Product Research. 2017:1 - 5. doi:10.1080/14786419.2017.1326489
Oliveira M, Junior PAdemar Sal, Rodrigues MJoão, et al. Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal. Asian Pac J Trop Med. 2016;9(8):735-41. doi:10.1016/j.apjtm.2016.06.015
Custódio L, Laukaityte S, Engelen AH, et al. A comparative evaluation of biological activities and bioactive compounds of the seagrasses Zostera marina and Zostera noltei from southern Portugal. Natural Product Research. 2016;30(6):724 - 728. doi:10.1080/14786419.2015.1040791
Pereira H, Custódio L, Rodrigues MJ, et al. Profiling of antioxidant potential and phytoconstituents of Plantago coronopus. Brazilian Journal of Biology. 2016;(ahead). doi:10.1590/1519-6984.02416
Pereira H, Gangadhar KN, Schulze PSC, et al. Isolation of a euryhaline microalgal strain, Tetraselmis sp. CTP4, as a robust feedstock for biodiesel production. Scientific Reports. 2016;6:35663. doi:10.1038/srep35663
Gangadhar KN, Pereira H, Diogo HP, et al. Assessment and comparison of the properties of biodiesel synthesized from three different types of wet microalgal biomass. Journal of Applied Phycology. 2016;28(3):1571 - 1578. doi:10.1007/s10811-015-0683-5
Ismael A, Henriques MSC, Marques C, et al. Exploring saccharinate-tetrazoles as selective Cu(. RSC Adv. 2016;6(75):71628 - 71637. doi:10.1039/C6RA15051A
Rodrigues MJoão, Neves V, Martins A, et al. In vitro antioxidant and anti-inflammatory properties of Limonium algarvense flowers' infusions and decoctions: A comparison with green tea (Camellia sinensis). Food Chem. 2016;200:322-9. doi:10.1016/j.foodchem.2016.01.048
Lopes A, Rodrigues MJoão, Pereira C, et al. Natural products from extreme marine environments: Searching for potential industrial uses within extremophile plants. Industrial Crops and Products. 2016;94:299 - 307. doi:10.1016/j.indcrop.2016.08.040
Vizetto-Duarte C, Pereira H, de Sousa CBruno, et al. Fatty acid profile of different species of algae of the Cystoseira genus: a nutraceutical perspective. Nat Prod Res. 2015;29(13):1264-70. doi:10.1080/14786419.2014.992343
Grosso C, Cardoso ALúcia, Lemos A, et al. Novel approach to bis(indolyl)methanes: de novo synthesis of 1-hydroxyiminomethyl derivatives with anti-cancer properties. Eur J Med Chem. 2015;93:9-15. doi:10.1016/j.ejmech.2015.01.050
Cravo A, Fernandes D, Damião T, Pereira C, Reis MP. Determining the footprint of sewage discharges in a coastal lagoon in South-Western Europe. Mar Pollut Bull. 2015;96(1-2):197-209. doi:10.1016/j.marpolbul.2015.05.029
Pereira H, Custódio L, Rodrigues MJoão, et al. Biological Activities and Chemical Composition of Methanolic Extracts of Selected Autochthonous Microalgae Strains from the Red Sea. Mar Drugs. 2015;13(6):3531-49. doi:10.3390/md13063531
Rodrigues MJoão, Gangadhar KN, Vizetto-Duarte C, et al. Maritime halophyte species from southern Portugal as sources of bioactive molecules. Mar Drugs. 2014;12(4):2228-44. doi:10.3390/md12042228
Martins DAlves, Custódio L, Barreira L, et al. Alternative sources of n-3 long-chain polyunsaturated fatty acids in marine microalgae. Mar Drugs. 2013;11(7):2259-81. doi:10.3390/md11072259
Pereira H, Barreira L, Figueiredo F, et al. Polyunsaturated Fatty acids of marine macroalgae: potential for nutritional and pharmaceutical applications. Mar Drugs. 2012;10(9):1920-35. doi:10.3390/md10091920
Custodio L, Fernandes E, Escapa AL, et al. Antioxidant and cytotoxic activities of carob tree fruit pulps are strongly influenced by gender and cultivar. J Agric Food Chem. 2011;59(13):7005-12. doi:10.1021/jf200838f
Pereira H, Barreira L, Mozes A, et al. Microplate-based high throughput screening procedure for the isolation of lipid-rich marine microalgae. Biotechnol Biofuels. 2011;4(1):61. doi:10.1186/1754-6834-4-61
Custódio L, Escapa ALuísa, Fernandes E, et al. Phytochemical profile, antioxidant and cytotoxic activities of the carob tree (Ceratonia siliqua L.) germ flour extracts. Plant Foods Hum Nutr. 2011;66(1):78-84. doi:10.1007/s11130-011-0214-8
Activity type 
Sala 2.31 I Edifício 7 I Campus Gambelas
Qua, 24/04/2019
Sala 2.31 I Edifício 7 I Campus Gambelas
Luísa Custódio trabalhou anteriormente no CCMAR como investigadora auxiliar e juntou-se ao grupo XtremeBio. Parabéns à nova posição Luísa!