XtremeBio | - CCMAR -


Short Title 

We are engaged in the smart and sustainable exploitation of marine resources, including micro- and macroalgae, seagrasses, marine invertebrates and also coastal plants (halophytes).




Our research is divided in 5 sub areas: XtremeFoods (for human nutrition); XtremePharma (for pharmaceutical uses), XtremeVet (for veterinary aplications); XtremeBeauty (for cosmetics) and XtremeCrops (Production of selected species).

Most relevant expected contributions of this research team includes the development and optimization of innovative commercial products incorporating active extracts from selected marine species, to be used in different commercial areas, and of sustainable cultivation technologies, such as in vitro techniques, greenhouse cultivation and IMTA systems, aiming the production of biomass and ingredients for commercial purposes.



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Retrato de Catarina Guerreiro Pereira
Retrato de Cristiana do Couto Pereira Maia
PhD Student
Retrato de Eliana Fernandes
PhD Student
Retrato de Maria João da Silva Rodrigues
Retrato de Marta Oliveira
Todas publicações
Rosa A, Cardeira S, Pereira C, et al. Temporal variability of the mass exchanges between the main inlet of Ria Formosa lagoon (southwestern Iberia) and the Atlantic Ocean. Estuarine, Coastal and Shelf Science. 2019;228:106349. doi:10.1016/j.ecss.2019.106349
Trampetti F, Pereira C, Rodrigues MJoão, et al. Exploring the halophyte Cistanche phelypaea (L.) Cout as a source of health promoting products: In vitro antioxidant and enzyme inhibitory properties, metabolomic profile and computational studies. Journal of Pharmaceutical and Biomedical Analysis. 2019;165:119 - 128. doi:10.1016/j.jpba.2018.11.053
Vizetto-Duarte C, Figueiredo F, Rodrigues MJoão, Polo C, Rešek E, Custódio L. Sustainable Valorization of Halophytes from the Mediterranean Area: A Comprehensive Evaluation of Their Fatty Acid Profile and Implications for Human and Animal Nutrition. Sustainability. 2019;11(8):2197. doi:10.3390/su11082197
Zengin G, Mahomoodally MFawzi, Paksoy MYavuz, et al. Phytochemical characterization and bioactivities of five Apiaceae species: Natural sources for novel ingredients. Industrial Crops and Products. 2019;135:107 - 121. doi:10.1016/j.indcrop.2019.04.033
Zengin G, Paksoy MYavuz, Aumeeruddy MZakariyyah, et al. New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species. Food Research International. 2019;123:414 - 424. doi:10.1016/j.foodres.2019.05.013
Zengin G, Stefanucci A, Rodrigues MJoão, et al. Scrophularia lucida L. as a valuable source of bioactive compounds for pharmaceutical applications: In vitro antioxidant, anti-inflammatory, enzyme inhibitory properties, in silico studies, and HPLC profiles. Journal of Pharmaceutical and Biomedical Analysis. 2019;162:225 - 233. doi:10.1016/j.jpba.2018.09.035
Dra LAit, Rodrigues MJoão, Neng Nda Rosa, et al. Exploring Caralluma europaea (Guss.) N.E.Br. as a potential source of bioactive molecules: In vitro antioxidant and antidiabetic properties, and phenolic profile of crude extracts and fractions. Industrial Crops and Products. 2019;139:111527. doi:10.1016/j.indcrop.2019.111527
Mota AHenriques, Direito R, Carrasco MP, et al. Combination of hyaluronic acid and PLGA particles as hybrid systems for viscosupplementation in osteoarthritis. International Journal of Pharmaceutics. 2019;559:13 - 22. doi:10.1016/j.ijpharm.2019.01.017
Rodrigues MJoão, Matkowski A, Slusarczyk S, et al. Sea knotgrass (Polygonum maritimum L.) as a potential source of innovative industrial products for skincare applications. Industrial Crops and Products. 2019;128:391 - 398. doi:10.1016/j.indcrop.2018.11.038
Rodrigues MJoão, Monteiro I, Placines C, et al. Dataset on functional and chemical properties of the medicinal halophyte Polygonum maritimum L. under greenhouse cultivation. Data in Brief. 2019;25:104357. doi:10.1016/j.dib.2019.104357
Rodrigues MJoão, Monteiro I, Placines C, et al. The irrigation salinity and harvesting affect the growth, chemical profile and biological activities of Polygonum maritimum L. Industrial Crops and Products. 2019;139:111510. doi:10.1016/j.indcrop.2019.111510
Rodrigues MJoão, Slusarczyk S, Pecio Ł, et al. In vitro and in silico approaches to appraise Polygonum maritimum L. as a source of innovative products with anti-ageing potential. Industrial Crops and Products. 2018;111:391 - 399. doi:10.1016/j.indcrop.2017.10.046
Barreira L, Rešek E, Rodrigues MJoão, et al. Halophytes: Gourmet food with nutritional health benefits?. Journal of Food Composition and Analysis. 2017;59:35 - 42. doi:10.1016/j.jfca.2017.02.003
Pereira CGuerreiro, Barreira L, Bijttebier S, et al. Chemical profiling of infusions and decoctions of Helichrysum italicum subsp. picardii by UHPLC-PDA-MS and in vitro biological activities comparatively with green tea ( Camellia sinensis ) and rooibos tisane ( Aspalathus linearis ). Journal of Pharmaceutical and Biomedical Analysis. 2017;145:593 - 603. doi:10.1016/j.jpba.2017.07.007
Braga T, Rodrigues MJoão, Pereira H, et al. Bursatella leachii from Mar Menor as a Source of Bioactive Molecules: Preliminary Evaluation of the Nutritional Profile, In Vitro Biological Activities, and Fatty Acids Contents. Journal of Aquatic Food Product Technology. 2017;26(10):1337 - 1350. doi:10.1080/10498850.2017.1392670
Oliveira M, Rodrigues MJoão, Pereira C, et al. First report of the in vitro antileishmanial properties of extremophile plants from the Algarve Coast. Natural Product Research. 2017:1 - 5. doi:10.1080/14786419.2017.1326489
Rocha MI, Rodrigues MJ, Pereira C, et al. Biochemical profile and in vitro neuroprotective properties of Carpobrotus edulis L., a medicinal and edible halophyte native to the coast of South Africa. South African Journal of Botany. 2017;111:222 - 231. doi:10.1016/j.sajb.2017.03.036
Oliveira M, Junior PAdemar Sal, Rodrigues MJoão, et al. Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal. Asian Pac J Trop Med. 2016;9(8):735-41. doi:10.1016/j.apjtm.2016.06.015
Custódio L, Laukaityte S, Engelen AH, et al. A comparative evaluation of biological activities and bioactive compounds of the seagrasses Zostera marina and Zostera noltei from southern Portugal. Natural Product Research. 2016;30(6):724 - 728. doi:10.1080/14786419.2015.1040791
Rodrigues MJoão, Neves V, Martins A, et al. In vitro antioxidant and anti-inflammatory properties of Limonium algarvense flowers' infusions and decoctions: A comparison with green tea (Camellia sinensis). Food Chem. 2016;200:322-9. doi:10.1016/j.foodchem.2016.01.048
Ismael A, Henriques MSC, Marques C, et al. Exploring saccharinate-tetrazoles as selective Cu(. RSC Adv. 2016;6(75):71628 - 71637. doi:10.1039/C6RA15051A
Lopes A, Rodrigues MJoão, Pereira C, et al. Natural products from extreme marine environments: Searching for potential industrial uses within extremophile plants. Industrial Crops and Products. 2016;94:299 - 307. doi:10.1016/j.indcrop.2016.08.040
Pereira H, Custódio L, Rodrigues MJ, et al. Profiling of antioxidant potential and phytoconstituents of Plantago coronopus. Brazilian Journal of Biology. 2016;(ahead). doi:10.1590/1519-6984.02416
Grosso C, Cardoso ALúcia, Lemos A, et al. Novel approach to bis(indolyl)methanes: de novo synthesis of 1-hydroxyiminomethyl derivatives with anti-cancer properties. Eur J Med Chem. 2015;93:9-15. doi:10.1016/j.ejmech.2015.01.050
Cravo A, Fernandes D, Damião T, Pereira C, Reis MP. Determining the footprint of sewage discharges in a coastal lagoon in South-Western Europe. Mar Pollut Bull. 2015;96(1-2):197-209. doi:10.1016/j.marpolbul.2015.05.029
Pereira H, Custódio L, Rodrigues MJoão, et al. Biological Activities and Chemical Composition of Methanolic Extracts of Selected Autochthonous Microalgae Strains from the Red Sea. Mar Drugs. 2015;13(6):3531-49. doi:10.3390/md13063531
Rodrigues MJoão, Gangadhar KN, Vizetto-Duarte C, et al. Maritime halophyte species from southern Portugal as sources of bioactive molecules. Mar Drugs. 2014;12(4):2228-44. doi:10.3390/md12042228
Título do Projeto Coordenador Período Financiamento CCMAR Total
ManaCruzi Marine Natural Products Against T. cruzi 01/01/2014 a 31/12/2015 FCT
XTREMEBIO Halófitas: um recurso precioso de elementos nutricionais e compostos bioactivos Luísa Custódio 01/05/2013 a 31/08/2015 FCT 135.21k€
SEABIOMED Organismos fotossintéticos marinhos da costa Algarvia com aplicações biomédicas Luísa Custódio 04/01/2010 a 30/04/2013 FCT 159.02k€
Título do Projeto Coordenador Período Financiamento CCMAR Total
HaloFarMs Development and Optimization of Halophyte-based Farming systems in salt-affected Mediterranean Soils 01/10/2020 1.000,00k€
Tipo de Evento 
Sala 2.31 I Edifício 7 I Campus Gambelas
Qua, 24/04/2019
Sala 2.31 I Edifício 7 I Campus Gambelas
Luísa Custódio trabalhou anteriormente no CCMAR como investigadora auxiliar e juntou-se ao grupo XtremeBio. Parabéns à nova posição Luísa!
Catarina Guerreiro Pereira apresentou e defendeu a sua tese sobre “Chemical and biological characterization of halophyte plants with ethnopharmacological use in the Algarve coast”.
Viana Loaiza, juntou-se ao grupo de investicação XtremeBio. Bem-vinda à equipa!