Ana Grenha | CCMAR

Ana Grenha

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ORCID

Posições

Professor Universitário

Cargos

Membro da Direção do CCMAR

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Grupo

Marine Molecular Bioengineering

Local de trabalho

UALG - Faro (Campus de Gambelas)

amgrenha@ualg.pt

The Drug Delivery Lab at UAlg is breathing since 2010.

Sobre mim

Ana Grenha has received her PhD in Pharmacy-Pharmaceutical Technology from the University of Santiago de Compostela – Spain in 2007. She joined the University of Algarve in Portugal for a Professorship in Pharmaceutical Technology in 2007 and received her Habilitation in Pharmaceutical Technology at the University of Lisbon in 2022. Since July 2023 she is Associate Professor in Pharmaceutical Technology. She is a Senior Researcher at the Centre for Marine Sciences (CCMAR-UAlg) and an active collaborator of the iMed from the Faculty of Pharmacy of the University of Lisbon, being the PI of the Drug Delivery Laboratory, which is mainly dedicated to respiratory drug delivery, with a particular focus on inhalation. The research group is also keen on exploring the potential of natural materials, namely polysaccharides, fostering new applications that benefit from their intrinsic properties.

She has been the PI of several funded projects, and has authored ca. 50 papers in international peer-reviewed journals, 6 book chapters and 2 patents (1 pending) in the field of drug inhalation. She has supervised 4 PhD thesis and approximately 15 Master thesis, all in the field of drug delivery. She was recently awarded the prize Investigador Universidade do Algarve 2022 (University of Algarve Researcher 2022) and in 2020 received the Robalo Cordeiro Award from the Portuguese Society of Pneumology, attributed to a scientific project on pulmonary immunisation strategies.

She is currently the Director of the Integrated Master in Pharmaceutical Sciences at UAlg, is a member of the Board of Directors of CCMAR-UAlg since 2018 and is part of the Drug Delivery to the Lungs (DDL) Conference Committee since 2019.

Membro dos projetos

The imprinting characteristics of spermatogonia antioxidant capacity and their role in oxidative stress tolerance

GERMROS

Most recent papers:

Z Nuc, G Brusotti, L Catenacci, A Grenha, JF Pontes, J Pinto da Silva, AM Rosa da Costa, P Moro, C Milanese, P Grisoli, M Sorrenti, A Dobrzycka-Krahel, MC Bonferoni, C Caramella, 2023. Astacus leptodactylus (Eschscholtz, 1823) and Faxonius limosus (Rafinesque, 1817) as new, alternative sources of chitin and chitosan. Water, 15: 3024. Doi: 10.3390/w15173024

F Guerreiro, MM Gaspar, JF Pontes, AM Rosa da Costa, ML Faleiro, A Grenha, 2023. Respirable konjac glucomannan microparticles as antitubercular drug carriers: effects of in vitro and in vivo interactions. International Journal of Biological Macromolecules, 248: 125838. doi: 10.1016/j.ijbiomac.2023.125838

N Flórez-Fernández, JF Pontes, F Guerreiro, I Afonso, G Lollo, MD Torres, H Domínguez, AM Rosa da Costa, A Grenha, 2023. Fucoidan from Fucus vesiculosus: Evaluation of the impact of the sulphate content on nanoparticle production and cell toxicity. Marine Drugs, 21, 115. Doi: 10.3390/md21020115

A Grenha, F Guerreiro, JP Lourenço, JA Lopes, F Cámara-Martos, 2023. Microencapsulation of selenium by spray-drying as a tool to improve bioaccessibility in food matrix. Food Chemistry, 402, 134463. doi: 10.1016/j.foodchem.2022.134463

F Guerreiro, M Swedrowska, R Patel, N Flórez-Fernández, MD Torres, AM Rosa da Costa, B Forbes, A Grenha, 2021. Engineering of konjac glucomannan into respirable microparticles for delivery of antitubercular drugs. International Journal of Pharmaceutics, 604:120731. doi: 10.1016/j.ijpharm.2021.120731

A Rosso, V Andretto, Y Chevalier, D Kryza, J Sidi-Boumedine, A Grenha, F Guerreiro, A Gharsallaoui, N Lebaz, V La Padula, AC Montembault, L David, S Briançon, G Lollo, 2021. Nanocomposite sponges for enhancing intestinal residence time following oral administration. Journal of Controlled Release, 333:579-592. doi: 10.1016/j.jconrel.2021.04.004

S Rodrigues, L Cunha, J Kollan, PR Neumann, AM Rosa da Costa, LA Dailey, A Grenha, 2021. Cytocompatibility and cellular interactions of chondroitin sulfate microparticles designed for inhaled tuberculosis treatment. European Journal of Pharmaceutics and Biopharmaceutics, 163: 171-178. doi: 10.1016/j.ejpb.2021.04.001

Patents:

A Grenha, JF Pontes, RM Borges dos Santos, E Conceição, H Diogo. Portable device to study the exposure of cells to dry powders. WO/2023/073658, PCT/IB2022/060464 (pending).

AD Alves, FS Pereira, S Rodrigues, F Guerreiro, L Cunha, A Grenha, Process for producing polysaccharide microparticles for alveolar macrophages targeting, microparticles obtained therein and use thereof. WO/2016/174573, PCT/IB2016/052353. - converted: granted in March 2022.