Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization

Braz, Luis; Ana Grenha; Ferreira, Domingos; Rosa da Costa, Ana M.; Gamazo, Carlos; Sarmento, Bruno

Ana Grenha

Position

Senior Researcher

Academic Degree

Doutoramento

Group

Marine Molecular Bioengineering

Professor Category

Assistant

Institution

University of Algarve, Faculty of Sciences and Technology

Based at

Faro, Gambelas Campus, UAlg

Office Nr

3.1, Bld 8

Phone Nr

+351 289800100

Extension

7441

amgrenha@ualg.pt

Keywords

Drug delivery, Encapsulation processes, Nanoparticles, Microparticles, Polysaccharide-based carriers

ORCID ID

Organiza

Activities

Activity type

Outros Eventos

Defesa da tese de doutoramento da Ludmylla Cunha

Esta sexta-feira, 1 de Fevereiro, será um dia especial para a estudante de doutoramento Ludmylla Cunha: vai defender a sua tese de doutoramento, que teve a orientação da investigadora Ana Grenha...

Sex, 01/02/2019

Anfiteatro Verde, Building 8, Gambelas Campus

News

CCMAR marca presença no 4º Congresso Internacional de Áreas Marinhas Protegidas (IMPAC4)

O CCMAR marcou presença no 4º Congresso Internacional de Áreas Marinhas Protegidas (IMPAC4), que ocorreu no Chile de 4 a 8 de Setembro de 2017.

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Três investigadoras do CCMAR receberam prémios Tech2Market

Ana Grenha receives her Tech2Market honorable mention (photo credits: UAlg Communication Department)

Ana Grenha, Maria Clara Costa e Luísa Custódio receberam menções honrosas no concurso Tech2Market promovido pela Universidade do Algarve. Fomos falar com as investigadoras para saber mais sobre as suas tecnologias e futuras prospectivas.

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Publications

Selected Publications

Braz L, Grenha A, Ferreira D, da Costa AMRosa, Gamazo C, Sarmento B. Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization. International Journal of Biological Macromolecules. 2017;96:786 - 797. doi:10.1016/j.ijbiomac.2016.12.076

Publications

Year of Publication
2017	Braz L, Grenha A, Ferreira D, da Costa AMRosa, Gamazo C, Sarmento B. Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization. International Journal of Biological Macromolecules. 2017;96:786 - 797. doi:10.1016/j.ijbiomac.2016.12.076 Ler mais acerca de Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization Google Scholar DOI
2016	Alves AD, Cavaco JS, Guerreiro F, Lourenço JP, da Costa AMRosa, Grenha A. Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles. Molecules. 2016;21(6). doi:10.3390/molecules21060702 Ler mais acerca de Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles. Google Scholar PubMed DOI
2016	Cunha L, Grenha A. Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications. Marine Drugs. 2016;14(3):42. doi:10.3390/md14030042 Ler mais acerca de Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications Google Scholar DOI
2016	Dionísio M, Braz L, Corvo M, Lourenço JP, Grenha A, da Costa AMRosa. Charged pullulan derivatives for the development of nanocarriers by polyelectrolyte complexation. International Journal of Biological Macromolecules. 2016;86:129 - 138. doi:10.1016/j.ijbiomac.2016.01.054 Ler mais acerca de Charged pullulan derivatives for the development of nanocarriers by polyelectrolyte complexation Google Scholar DOI
2015	Rodrigues S, Grenha A. Activation of Macrophages: Establishing a Role for Polysaccharides in Drug Delivery Strategies Envisaging Antibacterial Therapy. Current Pharmaceutical Design. 2015;21(33):4869 - 4887. doi:10.2174/1381612821666150820103910 Ler mais acerca de Activation of Macrophages: Establishing a Role for Polysaccharides in Drug Delivery Strategies Envisaging Antibacterial Therapy Google Scholar DOI
2015	Rodrigues S, Cardoso L, da Costa A, Grenha A. Biocompatibility and Stability of Polysaccharide Polyelectrolyte Complexes Aimed at Respiratory Delivery. Materials. 2015;8(9):5647 - 5670. doi:10.3390/ma8095268 Ler mais acerca de Biocompatibility and Stability of Polysaccharide Polyelectrolyte Complexes Aimed at Respiratory Delivery Google Scholar DOI
2015	Grenha A. Editorial (Thematic Issue: Exploring the Role of Polysaccharides in Drug Delivery). Current Pharmaceutical Design. 2015;21(33):4773 - 4774. doi:10.2174/1381612821999150903143853 Ler mais acerca de Editorial (Thematic Issue: Exploring the Role of Polysaccharides in Drug Delivery) Google Scholar DOI
2015	Santos MA dos, Grenha A. Advances In Protein Chemistry And Structural Biologyprotein And Peptide Nanoparticles For Drug Deliverypolysaccharide Nanoparticles For Protein And Peptide Delivery. Vol. 98. Elsevier; 2015:223 - 261. doi:10.1016/bs.apcsb.2014.11.003 Ler mais acerca de Advances in Protein Chemistry and Structural BiologyProtein and Peptide Nanoparticles for Drug DeliveryPolysaccharide Nanoparticles for Protein and Peptide Delivery Google Scholar DOI
2015	Rodrigues S, Cordeiro C, Seijo B, Remuñán-López C, Grenha A. Hybrid nanosystems based on natural polymers as protein carriers for respiratory delivery: Stability and toxicological evaluation. Carbohydrate Polymers. 2015;123:369 - 380. doi:10.1016/j.carbpol.2015.01.048 Ler mais acerca de Hybrid nanosystems based on natural polymers as protein carriers for respiratory delivery: Stability and toxicological evaluation Google Scholar DOI
2014	Perestrelo ARubina, Grenha A, da Costa AMRosa, Belo JAntónio. Locust bean gum as an alternative polymeric coating for embryonic stem cell culture. Materials Science and Engineering: C. 2014;40:336 - 344. doi:10.1016/j.msec.2014.04.022 Ler mais acerca de Locust bean gum as an alternative polymeric coating for embryonic stem cell culture Google Scholar DOI
2014	Nunes R, Rodrigues S, Pasko P, Tyszka-Czochara M, Grenha A, de Carvalho ISaraiva. Effect of Erica australis extract on Caco-2 cells, fibroblasts and selected pathogenic bacteria responsible for wound infection. Industrial Crops and Products. 2014;52:99 - 104. doi:10.1016/j.indcrop.2013.10.015 Ler mais acerca de Effect of Erica australis extract on Caco-2 cells, fibroblasts and selected pathogenic bacteria responsible for wound infection Google Scholar DOI
2013	Grenha A, Rodrigues S. Pullulan-based nanoparticles: future therapeutic applications in transmucosal protein delivery. Therapeutic Delivery. 2013;4(11):1339 - 1341. doi:10.4155/tde.13.99 Ler mais acerca de Pullulan-based nanoparticles: future therapeutic applications in transmucosal protein delivery Google Scholar DOI
2013	Dionísio M, Cordeiro C, Remuñán-López C, Seijo B, da Costa AMRosa, Grenha A. Pullulan-based nanoparticles as carriers for transmucosal protein delivery. European Journal of Pharmaceutical Sciences. 2013;50(1):102 - 113. doi:10.1016/j.ejps.2013.04.018 Ler mais acerca de Pullulan-based nanoparticles as carriers for transmucosal protein delivery Google Scholar DOI
2013	Costa H, Grenha A. Natural carriers for application in tuberculosis treatment. Journal of Microencapsulation. 2013;30(3):295 - 306. doi:10.3109/02652048.2012.726283 Ler mais acerca de Natural carriers for application in tuberculosis treatment Google Scholar DOI
2012	Rodrigues S, Dionísio M, López CRemuñán, Grenha A. Biocompatibility of Chitosan Carriers with Application in Drug Delivery. Journal of Functional Biomaterials. 2012;3(4):615 - 641. doi:10.3390/jfb3030615 Ler mais acerca de Biocompatibility of Chitosan Carriers with Application in Drug Delivery Google Scholar DOI
2012	Grenha A, Dionísio M. Locust bean gum: Exploring its potential for biopharmaceutical applications. Journal of Pharmacy and Bioallied Sciences. 2012;4(3):175. doi:10.4103/0975-7406.99013 Ler mais acerca de Locust bean gum: Exploring its potential for biopharmaceutical applications Google Scholar DOI
2012	Rodrigues S, da Costa AMRosa, Grenha A. Chitosan/carrageenan nanoparticles: Effect of cross-linking with tripolyphosphate and charge ratios. Carbohydrate Polymers. 2012;89(1):282 - 289. doi:10.1016/j.carbpol.2012.03.010 Ler mais acerca de Chitosan/carrageenan nanoparticles: Effect of cross-linking with tripolyphosphate and charge ratios Google Scholar DOI
2012	Grenha A. Chitosan nanoparticles: a survey of preparation methods. Journal of Drug Targeting. 2012;20(4):291 - 300. doi:10.3109/1061186X.2011.654121 Ler mais acerca de Chitosan nanoparticles: a survey of preparation methods Google Scholar DOI
2012	Al-Qadi S, Grenha A, Carrión-Recio D, Seijo B, Remuñán-López C. Microencapsulated chitosan nanoparticles for pulmonary protein delivery: In vivo evaluation of insulin-loaded formulations. Journal of Controlled Release. 2012;157(3):383 - 390. doi:10.1016/j.jconrel.2011.08.008 Ler mais acerca de Microencapsulated chitosan nanoparticles for pulmonary protein delivery: In vivo evaluation of insulin-loaded formulations Google Scholar DOI

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