XtremeBio | - CCMAR -

XtremeBio

Short Title 
XtremeBio
Descrição 

We are engaged in the smart and sustainable exploitation of marine resources, including micro- and macroalgae, seagrasses, marine invertebrates and also coastal plants (halophytes).

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Sobre

Our research is divided in 5 sub areas: XtremeFoods (for human nutrition); XtremePharma (for pharmaceutical uses), XtremeVet (for veterinary aplications); XtremeBeauty (for cosmetics) and XtremeCrops (Production of selected species).

Most relevant expected contributions of this research team includes the development and optimization of innovative commercial products incorporating active extracts from selected marine species, to be used in different commercial areas, and of sustainable cultivation technologies, such as in vitro techniques, greenhouse cultivation and IMTA systems, aiming the production of biomass and ingredients for commercial purposes.

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Retrato de Catarina Guerreiro Pereira
Posição:
Investigador
Retrato de Cristiana do Couto Pereira Maia
Posição:
PhD Student
Retrato de Eliana Fernandes
Posição:
PhD Student
Retrato de Maria João da Silva Rodrigues
Posição:
Postdoc
Retrato de Marta Oliveira
Posição:
Galeria
Publicações
Todas publicações
Zengin G, Sinan KIbrahime, Ak G, et al. Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study. Industrial Crops and Products. 2020;153:112572. doi:10.1016/j.indcrop.2020.112572
Castañeda-Loaiza V, Placines C, Rodrigues MJoão, et al. If you cannot beat them, join them: Exploring the fruits of the invasive species Carpobrotus edulis (L.) N.E. Br as a source of bioactive products. Industrial Crops and Products. 2020;144:112005. doi:10.1016/j.indcrop.2019.112005
Castañeda-Loaiza V, Placines C, Rodrigues MJoão, et al. In vitro enzyme inhibitory and anti-oxidant properties, cytotoxicity and chemical composition of the halophyte Malcolmia littorea (L.) R.Br. (Brassicaceae). Natural Product Research. 2020:1 - 4. doi:10.1080/14786419.2020.1719484
Gangadhar KN, Rodrigues MJoão, Pereira H, et al. Anti-Hepatocellular Carcinoma (HepG2) Activities of Monoterpene Hydroxy Lactones Isolated from the Marine Microalga Tisochrysis Lutea. Marine Drugs. 2020;18(11):567. doi:10.3390/md18110567
Mota AHenriques, Andrade JM, Rodrigues MJoão, et al. Synchronous insight of in vitro and in vivo biological activities of Sambucus nigra L. extracts for industrial uses. Industrial Crops and Products. 2020;154:112709. doi:10.1016/j.indcrop.2020.112709
Rodrigues MJoão, Monteiro I, Castañeda-Loaiza V, et al. Growth performance, in vitro antioxidant properties and chemical composition of the halophyte Limonium algarvense Erben are strongly influenced by the irrigation salinity. Industrial Crops and Products. 2020;143:111930. doi:10.1016/j.indcrop.2019.111930
Trentin R, Custódio L, Rodrigues MJoão, et al. Exploring Ulva australis Areschoug for possible biotechnological applications: In vitro antioxidant and enzymatic inhibitory properties, and fatty acids contents. Algal Research. 2020;50:101980. doi:10.1016/j.algal.2020.101980
Dra LAit, Rodrigues MJoão, Neng Nda Rosa, et al. Exploring Caralluma europaea (Guss.) N.E.Br. as a potential source of bioactive molecules: In vitro antioxidant and antidiabetic properties, and phenolic profile of crude extracts and fractions. Industrial Crops and Products. 2019;139:111527. doi:10.1016/j.indcrop.2019.111527
Mota AHenriques, Direito R, Carrasco MP, et al. Combination of hyaluronic acid and PLGA particles as hybrid systems for viscosupplementation in osteoarthritis. International Journal of Pharmaceutics. 2019;559:13 - 22. doi:10.1016/j.ijpharm.2019.01.017
Rodrigues MJoão, Matkowski A, Slusarczyk S, et al. Sea knotgrass (Polygonum maritimum L.) as a potential source of innovative industrial products for skincare applications. Industrial Crops and Products. 2019;128:391 - 398. doi:10.1016/j.indcrop.2018.11.038
Rodrigues MJoão, Monteiro I, Placines C, et al. Dataset on functional and chemical properties of the medicinal halophyte Polygonum maritimum L. under greenhouse cultivation. Data in Brief. 2019;25:104357. doi:10.1016/j.dib.2019.104357
Rodrigues MJoão, Monteiro I, Placines C, et al. The irrigation salinity and harvesting affect the growth, chemical profile and biological activities of Polygonum maritimum L. Industrial Crops and Products. 2019;139:111510. doi:10.1016/j.indcrop.2019.111510
Rosa A, Cardeira S, Pereira C, et al. Temporal variability of the mass exchanges between the main inlet of Ria Formosa lagoon (southwestern Iberia) and the Atlantic Ocean. Estuarine, Coastal and Shelf Science. 2019;228:106349. doi:10.1016/j.ecss.2019.106349
Trampetti F, Pereira C, Rodrigues MJoão, et al. Exploring the halophyte Cistanche phelypaea (L.) Cout as a source of health promoting products: In vitro antioxidant and enzyme inhibitory properties, metabolomic profile and computational studies. Journal of Pharmaceutical and Biomedical Analysis. 2019;165:119 - 128. doi:10.1016/j.jpba.2018.11.053
Vizetto-Duarte C, Figueiredo F, Rodrigues MJoão, Polo C, Rešek E, Custódio L. Sustainable Valorization of Halophytes from the Mediterranean Area: A Comprehensive Evaluation of Their Fatty Acid Profile and Implications for Human and Animal Nutrition. Sustainability. 2019;11(8):2197. doi:10.3390/su11082197
Zengin G, Mahomoodally MFawzi, Paksoy MYavuz, et al. Phytochemical characterization and bioactivities of five Apiaceae species: Natural sources for novel ingredients. Industrial Crops and Products. 2019;135:107 - 121. doi:10.1016/j.indcrop.2019.04.033
Zengin G, Paksoy MYavuz, Aumeeruddy MZakariyyah, et al. New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species. Food Research International. 2019;123:414 - 424. doi:10.1016/j.foodres.2019.05.013
Zengin G, Stefanucci A, Rodrigues MJoão, et al. Scrophularia lucida L. as a valuable source of bioactive compounds for pharmaceutical applications: In vitro antioxidant, anti-inflammatory, enzyme inhibitory properties, in silico studies, and HPLC profiles. Journal of Pharmaceutical and Biomedical Analysis. 2019;162:225 - 233. doi:10.1016/j.jpba.2018.09.035
González-Wangüemert M, Roggatz CC, Rodrigues MJoão, Barreira L, da Silva MMoreira, Custódio L. A new insight into the influence of habitat on the biochemical properties of three commercial sea cucumber species. International Aquatic Research. 2018;10(4):361 - 373. doi:10.1007/s40071-018-0210-9
Rodrigues MJoão, Slusarczyk S, Pecio Ł, et al. In vitro and in silico approaches to appraise Polygonum maritimum L. as a source of innovative products with anti-ageing potential. Industrial Crops and Products. 2018;111:391 - 399. doi:10.1016/j.indcrop.2017.10.046
Pereira CGuerreiro, Barreira L, Bijttebier S, et al. Health promoting potential of herbal teas and tinctures from Artemisia campestris subsp. maritima: from traditional remedies to prospective products. Scientific Reports. 2018;8(1). doi:10.1038/s41598-018-23038-6
Rodrigues MJoão, Vizetto-Duarte C, Gangadhar KN, et al. In vitro and in silico approaches to unveil the mechanisms underlying the cytotoxic effect of juncunol on human hepatocarcinoma cells. Pharmacological Reports. 2018;70(5):896 - 899. doi:10.1016/j.pharep.2018.02.001
Roggatz CC, González-Wangüemert M, Pereira H, et al. A first glance into the nutritional properties of the sea cucumber Parastichopus regalis from the Mediterranean Sea (SE Spain). Natural Product Research. 2018;32(1):116 - 120. doi:10.1080/14786419.2017.1331224
Zengin G, Rodrigues MJoão, Abdallah HH, et al. Combination of phenolic profiles, pharmacological properties and in silico studies to provide new insights on Silene salsuginea from Turkey. Computational Biology and Chemistry. 2018;77:178 - 186. doi:10.1016/j.compbiolchem.2018.10.005
Barreira L, Rešek E, Rodrigues MJoão, et al. Halophytes: Gourmet food with nutritional health benefits?. Journal of Food Composition and Analysis. 2017;59:35 - 42. doi:10.1016/j.jfca.2017.02.003
Pereira CGuerreiro, Barreira L, Bijttebier S, et al. Chemical profiling of infusions and decoctions of Helichrysum italicum subsp. picardii by UHPLC-PDA-MS and in vitro biological activities comparatively with green tea ( Camellia sinensis ) and rooibos tisane ( Aspalathus linearis ). Journal of Pharmaceutical and Biomedical Analysis. 2017;145:593 - 603. doi:10.1016/j.jpba.2017.07.007
Braga T, Rodrigues MJoão, Pereira H, et al. Bursatella leachii from Mar Menor as a Source of Bioactive Molecules: Preliminary Evaluation of the Nutritional Profile, In Vitro Biological Activities, and Fatty Acids Contents. Journal of Aquatic Food Product Technology. 2017;26(10):1337 - 1350. doi:10.1080/10498850.2017.1392670
Oliveira M, Rodrigues MJoão, Pereira C, et al. First report of the in vitro antileishmanial properties of extremophile plants from the Algarve Coast. Natural Product Research. 2017:1 - 5. doi:10.1080/14786419.2017.1326489
Grosso C, Cardoso AL, Rodrigues MJoão, et al. Hetero-Diels-Alder approach to Bis(indolyl)methanes. Bioorganic & Medicinal Chemistry. 2017;25(3):1122 - 1131. doi:10.1016/j.bmc.2016.12.028
Lopes SMM, Sousa EP, Barreira L, Marques C, Rodrigues MJoão, Melo TMVDPin. Synthesis and anti-cancer activity of chiral tetrahydropyrazolo[1,5- a ]pyridine-fused steroids. Steroids. 2017;122:16 - 23. doi:10.1016/j.steroids.2017.03.006
Rodrigues MJoão, Gangadhar KN, Zengin G, et al. Juncaceae species as sources of innovative bioactive compounds for the food industry: In vitro antioxidant activity, neuroprotective properties and in silico studies. Food and Chemical Toxicology. 2017;107:590 - 596. doi:10.1016/j.fct.2017.04.006
Rocha MI, Rodrigues MJ, Pereira C, et al. Biochemical profile and in vitro neuroprotective properties of Carpobrotus edulis L., a medicinal and edible halophyte native to the coast of South Africa. South African Journal of Botany. 2017;111:222 - 231. doi:10.1016/j.sajb.2017.03.036
Rodrigues MJoão, Custódio L, Lopes A, et al. Unlocking the in vitro anti-inflammatory and antidiabetic potential of Polygonum maritimum. Pharmaceutical Biology. 2017;55(1):1348 - 1357. doi:10.1080/13880209.2017.1301493
Rodrigues MJoão, Neves V, Martins A, et al. In vitro antioxidant and anti-inflammatory properties of Limonium algarvense flowers' infusions and decoctions: A comparison with green tea (Camellia sinensis). Food Chem. 2016;200:322-9. doi:10.1016/j.foodchem.2016.01.048
Ismael A, Henriques MSC, Marques C, et al. Exploring saccharinate-tetrazoles as selective Cu(. RSC Adv. 2016;6(75):71628 - 71637. doi:10.1039/C6RA15051A
Lopes A, Rodrigues MJoão, Pereira C, et al. Natural products from extreme marine environments: Searching for potential industrial uses within extremophile plants. Industrial Crops and Products. 2016;94:299 - 307. doi:10.1016/j.indcrop.2016.08.040
Pereira H, Custódio L, Rodrigues MJ, et al. Profiling of antioxidant potential and phytoconstituents of Plantago coronopus. Brazilian Journal of Biology. 2016;(ahead). doi:10.1590/1519-6984.02416
Oliveira M, Junior PAdemar Sal, Rodrigues MJoão, et al. Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal. Asian Pac J Trop Med. 2016;9(8):735-41. doi:10.1016/j.apjtm.2016.06.015
Custódio L, Laukaityte S, Engelen AH, et al. A comparative evaluation of biological activities and bioactive compounds of the seagrasses Zostera marina and Zostera noltei from southern Portugal. Natural Product Research. 2016;30(6):724 - 728. doi:10.1080/14786419.2015.1040791
Grosso C, Cardoso ALúcia, Lemos A, et al. Novel approach to bis(indolyl)methanes: de novo synthesis of 1-hydroxyiminomethyl derivatives with anti-cancer properties. Eur J Med Chem. 2015;93:9-15. doi:10.1016/j.ejmech.2015.01.050
Cravo A, Fernandes D, Damião T, Pereira C, Reis MP. Determining the footprint of sewage discharges in a coastal lagoon in South-Western Europe. Mar Pollut Bull. 2015;96(1-2):197-209. doi:10.1016/j.marpolbul.2015.05.029
Pereira H, Custódio L, Rodrigues MJoão, et al. Biological Activities and Chemical Composition of Methanolic Extracts of Selected Autochthonous Microalgae Strains from the Red Sea. Mar Drugs. 2015;13(6):3531-49. doi:10.3390/md13063531
Rodrigues MJoão, Gangadhar KN, Vizetto-Duarte C, et al. Maritime halophyte species from southern Portugal as sources of bioactive molecules. Mar Drugs. 2014;12(4):2228-44. doi:10.3390/md12042228
Projetos
Título do Projeto Coordenador Período Financiamento CCMAR Total
SEABIOMED Organismos fotossintéticos marinhos da costa Algarvia com aplicações biomédicas Luísa Custódio 04/01/2010 a 30/04/2013 FCT 159.02k€
XTREMEBIO Halófitas: um recurso precioso de elementos nutricionais e compostos bioactivos Luísa Custódio 01/05/2013 a 31/08/2015 FCT 135.21k€
ManaCruzi Marine Natural Products Against T. cruzi 01/01/2014 a 31/12/2015 FCT
Título do Projeto Coordenador Período Financiamento CCMAR Total
HaloFarMs Development and Optimization of Halophyte-based Farming systems in salt-affected Mediterranean Soils 01/10/2020 1.000,00k€
Eventos
Tipo de Evento 
Seminário
Sala 2.31 I Edifício 7 I Campus Gambelas
Qua, 24/04/2019
Local 
Sala 2.31 I Edifício 7 I Campus Gambelas
Notícias
News 
Luísa Custódio trabalhou anteriormente no CCMAR como investigadora auxiliar e juntou-se ao grupo XtremeBio. Parabéns à nova posição Luísa!
Catarina Guerreiro Pereira apresentou e defendeu a sua tese sobre “Chemical and biological characterization of halophyte plants with ethnopharmacological use in the Algarve coast”.
Viana Loaiza, juntou-se ao grupo de investicação XtremeBio. Bem-vinda à equipa!