Calcium phosphate metabolism and bone disease in patients with homozygous thalassemia. | - CCMAR -

Journal Article

TitleCalcium phosphate metabolism and bone disease in patients with homozygous thalassemia.
Publication TypeJournal Article
Authorsde Vernejoul, MC, Girot, R, Gueris, J, M. Cancela, L, Bang, S, Bielakoff, J, Mautalen, C, Goldberg, D, Miravet, L
Year of Publication1982
JournalJ Clin Endocrinol Metab
Date Published1982 Feb
KeywordsAdolescent, Bone and Bones, Bone Development, Bone Diseases, Calcifediol, Calcium, Child, Child, Preschool, Homozygote, Humans, Hydroxycholecalciferols, Iron, Minerals, Phosphorus, Seasons, Thalassemia

Calcium and phosphate metabolism were studied in 22 patients with homozygous thalassemia. The overall results showed no significant difference for serum calcium, phosphorus, alkaline phosphatase, immunoreactive parathyroid hormone, or 25-hydroxyvitamin D between thalassemic and control children. However, during the winter, serum 25-hydroxycholecalciferol levels were very significantly decreased in thalassemic children. A study of the hands showed thin metacarpal cortices related to increased resorption. Histomorphometric study of four iliac bone biopsies showed normal osteoclastic resorption and decreased bone formation. Prussian blue staining and x-ray electron microprobe analysis showed iron deposits inside the bone. Whether this finding is critical in the pathogenesis of the bone disease in unknown.


Alternate JournalJ. Clin. Endocrinol. Metab.
PubMed ID7054221
CCMAR Authors