Relationship between bone GLA-protein (BGP) and calcidiol (25-hydroxycalciferol) in serum of breast-fed infants. | - CCMAR -

Journal Article

TitleRelationship between bone GLA-protein (BGP) and calcidiol (25-hydroxycalciferol) in serum of breast-fed infants.
Publication TypeJournal Article
AuthorsGruson, M, M. Cancela, L, Denne, MA, Miravet, L
Year of Publication1986
JournalEndocrinol Exp
Date Published1986 Aug
Keywords25-Hydroxyvitamin D 2, Alkaline Phosphatase, Bone and Bones, Breast Feeding, Calcitriol, Calcium, Calcium-Binding Proteins, Ergocalciferols, Female, Humans, Infant, Newborn, Lactation, Osteocalcin, Phosphorus, Pregnancy

The aim of this investigation was to study the bone metabolism in early infancy by establishing the relationship between serum osteocalcin levels and the hormonal vitamin D status of exclusively breast-fed infants during their first month of life. Calcium, phosphorus, alkaline phosphatase, 25-hydroxycalciferol (calcidiol), 1,25-dihydroxycalciferol (calcitriol) and osteocalcin (BGP or GLA-protein) were measured in 22 healthy lactating women and their paired breast-fed infants before and after supplementation (400 IU vitamin D per day). Prior to supplementation calcidiol, calcitriol and osteocalcin remained unchanged. Following supplementation there was an increase in all the parameters with the exception of calcitriol. The administration of vitamin D to breast-fed infants should in fact have an effect on bone activity as reflected by the increase in osteocalcin levels.


Alternate JournalEndocrinol. Exp.
PubMed ID3489605
CCMAR Authors