|Title||Improved regeneration and de novo bone formation in a diabetic zebrafish model treated with Paricalcitol and Cinacalcet|
|Publication Type||Journal Article|
|Authors||Carvalho, FR, Fernandes, AR, M. Cancela, L, Gavaia, P|
|Year of Publication||2017|
|Journal||Wound Repair and Regeneration|
Bone changes related to diabetes have been well stablished, but few strategies have been developed to prevent this growing health problem. In our work we propose to investigate the effects of calcitriol as well as of a vitamin D analog (paricalcitol) and a calcimimetic (cinacalcet), in fin regeneration and de novo mineralization in a zebrafish model of diabetes. Following exposure of diabetic transgenic Tg(ins:nfsb-mCherry) zebrafish to calcitriol, paricalcitol and cinacalcet, caudal fins were amputated to assess their effects on tissue regeneration.
|Short Title||Wound Rep Reg|