Structure-activity relationship studies for multitarget antithrombotic drugs. | - CCMAR -

Journal Article

TitleStructure-activity relationship studies for multitarget antithrombotic drugs.
Publication TypeJournal Article
AuthorsNeves, AR, Correia-da-Silva, M, Sousa, E, Pinto, M
Year of Publication2016
JournalFuture Med Chem
Date Published2016 Nov 15

Thrombosis is a complex process involving multiple pathways. Currently, therapy relies on the combination of two or more antithrombotic drugs, showing that inhibiting more than one target provides benefits in the prevention and treatment of thrombosis. This review focuses on structure-activity relationship studies of molecules possessing multiple actions against thrombosis, namely, dual inhibitors of coagulation, dual inhibitors of coagulation and platelet aggregation, and also dual inhibitors of platelet aggregation. EP217609 has just entered clinical trials, which raise the expectations on the multitarget strategy to prevent or treat thrombosis.


Alternate JournalFuture Med Chem
PubMed ID27845573
CCMAR Authors