Microbial communities and bioactive compounds in marine sponges of the family irciniidae-a review. | - CCMAR -

Journal Article

TitleMicrobial communities and bioactive compounds in marine sponges of the family irciniidae-a review.
Publication TypeJournal Article
AuthorsHardoim, CCP, Costa, R
Year of Publication2014
JournalMar Drugs
Volume12
Issue10
Date Published2014 Sep 30
Pagination5089-122
ISSN1660-3397
KeywordsAnimals, Archaea, Bacteria, Fungi, Humans, Porifera, Quorum Sensing, Symbiosis
Abstract

Marine sponges harbour complex microbial communities of ecological and biotechnological importance. Here, we propose the application of the widespread sponge family Irciniidae as an appropriate model in microbiology and biochemistry research. Half a gram of one Irciniidae specimen hosts hundreds of bacterial species-the vast majority of which are difficult to cultivate-and dozens of fungal and archaeal species. The structure of these symbiont assemblages is shaped by the sponge host and is highly stable over space and time. Two types of quorum-sensing molecules have been detected in these animals, hinting at microbe-microbe and host-microbe signalling being important processes governing the dynamics of the Irciniidae holobiont. Irciniids are vulnerable to disease outbreaks, and concerns have emerged about their conservation in a changing climate. They are nevertheless amenable to mariculture and laboratory maintenance, being attractive targets for metabolite harvesting and experimental biology endeavours. Several bioactive terpenoids and polyketides have been retrieved from Irciniidae sponges, but the actual producer (host or symbiont) of these compounds has rarely been clarified. To tackle this, and further pertinent questions concerning the functioning, resilience and physiology of these organisms, truly multi-layered approaches integrating cutting-edge microbiology, biochemistry, genetics and zoology research are needed.

DOI10.3390/md12105089
Sapientia

http://www.ncbi.nlm.nih.gov/pubmed/25272328?dopt=Abstract

Alternate JournalMar Drugs
PubMed ID25272328
PubMed Central IDPMC4210886
CCMAR Authors