Marques CL, M. Cancela L, Laizé V. Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related transcription factors. Gene. 2016;576(1 Pt 2):229-236. doi:10.1016/j.gene.2015.10.005

Rodrigues ET, Pardal MÂ, Laizé V, M. Cancela L, Oliveira PJ, Serafim TL. Cardiomyocyte H9c2 cells present a valuable alternative to fish lethal testing for azoxystrobin. Environ Pollut. 2015;206:619-26. doi:10.1016/j.envpol.2015.08.026

M. Cancela L, Laizé V, Conceição N. Matrix Gla protein and osteocalcin: from gene duplication to neofunctionalization. Arch Biochem Biophys. 2014;561:56-63. doi:10.1016/j.abb.2014.07.020

Tiago DM, Marques CL, Roberto VP, M. Cancela L, Laizé V. Mir-20a regulates in vitro mineralization and BMP signaling pathway by targeting BMP-2 transcript in fish. Arch Biochem Biophys. 2014;543:23-30. doi:10.1016/j.abb.2013.12.009

Cavaco S, Williamson MK, Rosa J, et al. Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase. Fish Physiol Biochem. 2014;40(3):731-8. doi:10.1007/s10695-013-9880-9

Vijayakumar P, Laizé V, Cardeira J, Trindade M, M. Cancela L. Development of an in vitro cell system from zebrafish suitable to study bone cell differentiation and extracellular matrix mineralization. Zebrafish. 2013;10(4):500-9. doi:10.1089/zeb.2012.0833

Viegas CSB, Simes DC, Williamson MK, et al. Sturgeon osteocalcin shares structural features with matrix Gla protein: evolutionary relationship and functional implications. J Biol Chem. 2013;288(39):27801-11. doi:10.1074/jbc.M113.450213

Parameswaran V, Laizé V, Gavaia P, M. Cancela L. ESSA1 embryonic stem like cells from gilthead seabream: a new tool to study mesenchymal cell lineage differentiation in fish. Differentiation. 2012;84(3):240-51. doi:10.1016/j.diff.2012.07.004

Rafael MS, Laizé V, Bensimon-Brito A, Leite RB, Schüle R, M. Cancela L. Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata. Cell Mol Life Sci. 2012;69(3):423-34. doi:10.1007/s00018-011-0754-y

M. Cancela L, Conceição N, Laizé V. Gla-rich protein, a new player in tissue calcification?. Adv Nutr. 2012;3(2):174-81. doi:10.3945/an.111.001685

Rafael MS, Laizé V, Florindo C, Ferraresso S, Bargelloni L, M. Cancela L. Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts. Biochimie. 2012;94(5):1128-34. doi:10.1016/j.biochi.2012.01.013

Tiago DM, Laizé V, Bargelloni L, Ferraresso S, Romualdi C, M. Cancela L. Global analysis of gene expression in mineralizing fish vertebra-derived cell lines: new insights into anti-mineralogenic effect of vanadate. BMC Genomics. 2011;12:310. doi:10.1186/1471-2164-12-310

Fonseca VG, Rosa J, Laizé V, Gavaia P, M. Cancela L. Identification of a new cartilage-specific S100-like protein up-regulated during endo/perichondral mineralization in gilthead seabream. Gene Expr Patterns. 2011;11(7):448-55. doi:10.1016/j.gep.2011.07.003

Tiago DM, M. Cancela L, Laizé V. Proliferative and mineralogenic effects of insulin, IGF-1, and vanadate in fish osteoblast-like cells. J Bone Miner Metab. 2011;29(3):377-82. doi:10.1007/s00774-010-0243-7

Laizé V, Tiago DM, Aureliano M, M. Cancela L. New insights into mineralogenic effects of vanadate. Cell Mol Life Sci. 2009;66(24):3831-6. doi:10.1007/s00018-009-0137-9

Tiago DM, Laizé V, M. Cancela L. Alternatively spliced transcripts of Sparus aurata insulin-like growth factor 1 are differentially expressed in adult tissues and during early development. Gen Comp Endocrinol. 2008;157(2):107-15. doi:10.1016/j.ygcen.2008.04.006

Viegas CSB, Simes DC, Laizé V, Williamson MK, Price PA, M. Cancela L. Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates. J Biol Chem. 2008;283(52):36655-64. doi:10.1074/jbc.M802761200

Tiago DM, Laizé V, M. Cancela L, Aureliano M. Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line. Cell Biol Toxicol. 2008;24(3):253-63. doi:10.1007/s10565-007-9034-x

Conceição N, Laizé V, Simões B, Pombinho AR, M. Cancela L. Retinoic acid is a negative regulator of matrix Gla protein gene expression in teleost fish Sparus aurata. Biochim Biophys Acta. 2008;1779(1):28-39. doi:10.1016/j.bbagrm.2007.11.003

Tiago DM, M. Cancela L, Aureliano M, Laizé V. Vanadate proliferative and anti-mineralogenic effects are mediated by MAPK and PI-3K/Ras/Erk pathways in a fish chondrocyte cell line. FEBS Lett. 2008;582(9):1381-5. doi:10.1016/j.febslet.2008.03.025

Fonseca VG, Laizé V, Valente M, M. Cancela L. Identification of an osteopontin-like protein in fish associated with mineral formation. FEBS J. 2007;274(17):4428-39. doi:10.1111/j.1742-4658.2007.05972.x

Rafael MS, Laizé V, M. Cancela L. Identification of Sparus aurata bone morphogenetic protein 2: molecular cloning, gene expression and in silico analysis of protein conserved features in vertebrates. Bone. 2006;39(6):1373-81. doi:10.1016/j.bone.2006.06.021

Laizé V, Pombinho AR, M. Cancela L. Characterization of Sparus aurata osteonectin cDNA and in silico analysis of protein conserved features: evidence for more than one osteonectin in Salmonidae. Biochimie. 2005;87(5):411-20. doi:10.1016/j.biochi.2005.01.008

Laizé V, Martel P, Viegas CSB, Price PA, M. Cancela L. Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates. J Biol Chem. 2005;280(29):26659-68. doi:10.1074/jbc.M500257200

Pombinho AR, Laizé V, Molha DM, Marques SMP, M. Cancela L. Development of two bone-derived cell lines from the marine teleost Sparus aurata; evidence for extracellular matrix mineralization and cell-type-specific expression of matrix Gla protein and osteocalcin. Cell Tissue Res. 2004;315(3):393-406. doi:10.1007/s00441-003-0830-1