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Filtros: Autor is Cancela, M. Leonor  [Clear All Filters]
2015
Fernández I, Cardeira J, Granadeiro L, Gavaia P, Laizé V, M. Cancela L. The use of in vivo imaging tools in zebrafish for drug discovery for bone development and homeostasis. Laboratory Animals. 2015;49:26 - 94. doi:10.1177/0023677215609551
Fernández I, Vijayakumar P, Marques C, M. Cancela L, Gavaia P, Laizé V. Zebrafish vitamin K epoxide reductases: expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure. Fish Physiology and Biochemistry. 2015;41(3):745-759. doi:10.1007/s10695-015-0043-z
2014
Silva IAL, Conceição N, Michou L, M. Cancela L. Can zebrafish be a valid model to study Paget's disease of bone?. Journal of Applied Ichthyology. 2014;30(4):678 - 688. doi:10.1111/jai.2014.30.issue-410.1111/jai.12523
Richard N, Fernández I, Wulff T, et al. Dietary supplementation with vitamin k affects transcriptome and proteome of Senegalese sole, improving larval performance and quality. Mar Biotechnol (NY). 2014;16(5):522-37. doi:10.1007/s10126-014-9571-2
Rosa JT, M. Cancela L, Laizé V. Ets1 regulates the transcription of a cartilage-specific S100 protein in gilthead seabream. Journal of Applied Ichthyology. 2014;30(4):707-712. doi:10.1111/jai.2014.30.issue-410.1111/jai.12534
Silva IAL, Cox CJ, Leite RB, M. Cancela L, Conceição N. Evolutionary conservation of TFIIH subunits: implications for the use of zebrafish as a model to study TFIIH function and regulation. Comp Biochem Physiol B Biochem Mol Biol. 2014;172-173:9-20. doi:10.1016/j.cbpb.2014.03.007
Laizé V, Gavaia P, M. Cancela L. Fish: a suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities. Drug Discovery Today: Disease Models. 2014;13:29-37. doi:10.1016/j.ddmod.2014.08.001
Simões B, Conceição N, Kelsh RN, M. Cancela L. Identification of cis -regulatory elements in the upstream regions of zebrafish runx3 through in silico analysis: implications for function. Journal of Applied Ichthyology. 2014;30(4):661 - 670. doi:10.1111/jai.2014.30.issue-410.1111/jai.12536
M. Cancela L, Laizé V, Conceição N. Matrix Gla protein and osteocalcin: from gene duplication to neofunctionalization. Arch Biochem Biophys. 2014;561:56-63. doi:10.1016/j.abb.2014.07.020
Tiago DM, Marques CL, Roberto VP, M. Cancela L, Laizé V. Mir-20a regulates in vitro mineralization and BMP signaling pathway by targeting BMP-2 transcript in fish. Arch Biochem Biophys. 2014;543:23-30. doi:10.1016/j.abb.2013.12.009
Roberto VP, Tiago DM, Silva IAL, M. Cancela L. MiR-29a is an enhancer of mineral deposition in bone-derived systems. Arch Biochem Biophys. 2014;564:173-83. doi:10.1016/j.abb.2014.09.006
Fernández I, Tiago DM, Laizé V, M. Cancela L, Gisbert E. Retinoic acid differentially affects in vitro proliferation, differentiation and mineralization of two fish bone-derived cell lines: Different gene expression of nuclear receptors and ECM proteins. Journal of Steroid Biochemistry and Molecular Biology. 2014;140:34-43. doi:10.1016/j.jsbmb.2013.11.012
Marques CL, Fernández I, Rosa J, Viegas MN, M. Cancela L, Laizé V. Spatiotemporal expression and retinoic acid regulation of bone morphogenetic proteins 2, 4 and 16 in Senegalese sole. Journal of Applied Ichthyology. 2014;30(4):713-720. doi:10.1111/jai.2014.30.issue-410.1111/jai.12539
Cavaco S, Williamson MK, Rosa J, et al. Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase. Fish Physiol Biochem. 2014;40(3):731-8. doi:10.1007/s10695-013-9880-9
Fernández I, Santos A, M. Cancela L, Laizé V, Gavaia P. Warfarin, a potential pollutant in aquatic environment acting through Pxr signaling pathway and γ-glutamyl carboxylation of vitamin K-dependent proteins. Environmental Pollution. 2014;194:86-95. doi:10.1016/j.envpol.2014.07.015
2013
Conceição N, Viegas M, Fidalgo J, M. Cancela L. Development and characterization of Xl1, a Xenopus laevis chondrocyte-like cell culture. Mol Cell Biochem. 2013;373(1-2):41-51. doi:10.1007/s11010-012-1473-x
Vijayakumar P, Laizé V, Cardeira J, Trindade M, M. Cancela L. Development of an in vitro cell system from zebrafish suitable to study bone cell differentiation and extracellular matrix mineralization. Zebrafish. 2013;10(4):500-9. doi:10.1089/zeb.2012.0833
Simão M, Gavaia P, Pinto J, Korng E, M. Cancela L. Establishing an in vitro system to study chondrocyte phenotypes associated to human hereditary hemochromatosis and identify molecular players involved in chondrocyte related iron metabolism. Bone Abstracts. 2013. doi:10.1530/boneabs.1.PP262
Leite RB, Milan M, Coppe A, et al. mRNA-Seq and microarray development for the Grooved Carpet shell clam, Ruditapes decussatus: a functional approach to unravel host-parasite interaction. BMC Genomics. 2013;14:741. doi:10.1186/1471-2164-14-741
Araujo NCP, Afonso R, Bringela A, M. Cancela L, Cristiano MLS, Leite RB. Peroxides with antiplasmodial activity inhibit proliferation of Perkinsus olseni, the causative agent of Perkinsosis in bivalves. Parasitol Int. 2013;62(6):575-82. doi:10.1016/j.parint.2013.06.010
Viegas CSB, Simes DC, Williamson MK, et al. Sturgeon osteocalcin shares structural features with matrix Gla protein: evolutionary relationship and functional implications. J Biol Chem. 2013;288(39):27801-11. doi:10.1074/jbc.M113.450213
Adrião A, Conceicão N, Gavaia P, M. Cancela L. Zebrafish as a model to study craniofacial phenotypes related to human MEF2C mutations. European Journal of Clinical Investigation. 2013;43:97 - 106. doi:10.1111/eci.2013.43.issue-s110.1111/eci.12088
2012
Conceição N, Fazenda C, M. Cancela L. Comparative gene promoter analysis: an in silico strategy to identify candidate regulatory factors for Gla Rich Protein. Journal of Applied Ichthyology. 2012;28(3):372 - 376. doi:10.1111/j.1439-0426.2012.02001.x
Bensimon-Brito A, Cardeira J, M. Cancela L, Huysseune A, Witten PEckhard. Distinct patterns of notochord mineralization in zebrafish coincide with the localization of Osteocalcin isoform 1 during early vertebral centra formation. BMC Dev Biol. 2012;12:28. doi:10.1186/1471-213X-12-28
Dionísio G, Campos C, Valente LMP, Conceição LEC, M. Cancela L, Gavaia P. Effect of egg incubation temperature on the occurrence of skeletal deformities in Solea senegalensis. Journal of Applied Ichthyology. 2012;28(3):471 - 476. doi:10.1111/j.1439-0426.2012.01996.x