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Araújo NCP, Barton V, Jones M, et al. Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates. Bioorg Med Chem Lett. 2009;19(7):2038-43. doi:10.1016/j.bmcl.2009.02.013